P Hewins
Overview
Explore the profile of P Hewins including associated specialties, affiliations and a list of published articles.
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6
Citations
116
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0
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Recent Articles
1.
Garvey M, Bradley C, Holden K, Hewins P, Ngui S, Tedder R, et al.
J Hosp Infect
. 2017 Feb;
96(2):157-162.
PMID: 28196726
Background: Hepatitis C virus (HCV) infection is a major health burden worldwide. A patient with no history of HCV infection while on a renal unit was found to seroconvert to...
2.
Hewins P, Morgan M, Holden N, Neil D, Williams J, Savage C, et al.
Kidney Int
. 2006 Mar;
69(3):605-15.
PMID: 16514436
In antineutrophil cytoplasm autoantibody (ANCA)-associated systemic vasculitis (ASV), autoantibody-induced neutrophil activation is believed to cause organ damage. In vitro, tumor necrosis factor alpha (TNFalpha) primes neutrophils for ANCA stimulation and...
3.
Holland M, Hewins P, Goodall M, Adu D, Jefferis R, Savage C
Clin Exp Immunol
. 2004 Sep;
138(1):183-92.
PMID: 15373923
A characteristic feature of Wegener's granulomatosis is the presence of antineutrophil cytoplasm antibodies (ANCA) to proteinase 3 (PR3). In vitro, ANCA activate neutrophils by co-ligating PR3 and FcgammaRIIa/IIIb receptors. ANCA...
4.
Day C, Hewins P, Savage C
Clin Exp Rheumatol
. 2004 Jan;
21(6 Suppl 32):S35-48.
PMID: 14740426
In recent years there have been substantial developments in the understanding of the pathogenesis of ANCA-associated vasculitidies. Animal models have now been developed that finally prove a direct pathogenic role...
5.
Radford D, Luu N, Hewins P, Nash G, Savage C
Arthritis Rheum
. 2002 Jan;
44(12):2851-61.
PMID: 11762946
Objective: Recruitment of neutrophils to sites of inflammation requires coordinated regulation of their capture, activation, and migration on vascular endothelium. This study examines whether exposure of neutrophils to antineutrophil cytoplasmic...
6.
Hewins P, Tervaert J, Savage C, Kallenberg C
Curr Opin Rheumatol
. 2000 Jan;
12(1):3-10.
PMID: 10647948
Wegener's granulomatosis is a multisystem disease characterized by granulomata of the respiratory tract and systemic necrotising vasculitis. There is a strong and specific association with autoantibodies directed against proteinase 3,...