P F Spano
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Explore the profile of P F Spano including associated specialties, affiliations and a list of published articles.
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229
Citations
1172
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Recent Articles
1.
Cavalleri L, Merlo Pich E, Millan M, Chiamulera C, Kunath T, Spano P, et al.
Mol Psychiatry
. 2017 Nov;
23(4):812-823.
PMID: 29158584
Among neurobiological mechanisms underlying antidepressant properties of ketamine, structural remodeling of prefrontal and hippocampal neurons has been proposed as critical. The suggested mechanism involves downstream activation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)...
2.
Fragni M, Bonini S, Bettinsoli P, Bodei S, Generali D, Bottini A, et al.
Naunyn Schmiedebergs Arch Pharmacol
. 2016 Feb;
389(5):529-38.
PMID: 26905520
Preclinical data indicate a direct anti-tumor effect of zoledronic acid (ZA) outside the skeleton, but its molecular mechanism is still not completely clarified. The aim of this study was to...
3.
Porrini V, Lanzillotta A, Branca C, Benarese M, Parrella E, Lorenzini L, et al.
Neuroscience
. 2014 Dec;
302:112-20.
PMID: 25450955
Activation of microglia associated with neuroinflammation and loss of phagocytic activity is considered to play a prominent role in the pathogenesis of Alzheimer's disease (AD). CHF5074 (CSP-1103) has been shown...
4.
Kumakura K, Carenzi A, Spano P, Trabucchi M
Neurochem Res
. 2013 Nov;
1(3):329-36.
PMID: 24271417
We have investigated the properties of dopamine-dependent adenylate cyclase in rat striatal homogenates, 20 h after reserpine treatment. In this experimental condition, we have found that the affinity of the...
5.
Liberini P, Nisoli E, Missale C, Memo M, Buonamici M, Rossi A, et al.
Neurochem Int
. 2010 May;
14(1):61-4.
PMID: 20504400
In the present study we investigated the effects of a single injection of reserpine on dopamine receptor function in rat striatum. The measurement of adenylate cyclase activity indicated that cAMP...
6.
Carboni E, Memo M, Tanda G, Carruba M, Spano P
Neurochem Int
. 2010 May;
7(2):279-84.
PMID: 20492925
Sulpiride is an antipsychotic drug endowed with the properties of a dopamine antagonist. The failure of sulpiride to inhibit neostriatal dopamine stimulated adenylate cyclase activity indicated that this drug is...
7.
Govoni S, Olgiati V, Trabucchi M, Garau L, Stefanini E, Spano P
Neurosci Lett
. 2009 Jul;
8(3):207-10.
PMID: 19605160
No abstract available.
8.
Sigala S, Bodei S, Missale C, Zani D, Simeone C, Cosciani Cunico S, et al.
Mol Cell Endocrinol
. 2008 Feb;
284(1-2):11-20.
PMID: 18280641
A dysregulation of the nerve growth factor (NGF)-mediated control of prostate cell growth is associated with the malignant progression of prostate epithelial cells. Exogenous NGF induced in prostate cancer (PCa)...
9.
Missale C, Fiorentini C, Busi C, Collo G, Spano P
Curr Top Med Chem
. 2006 May;
6(8):801-8.
PMID: 16719818
Dopamine and glutamate have been shown to extensively interact in the striatum, nucleus accumbens, hippocampus and prefrontal cortex, to regulate different physiological functions, including locomotor activity, positive reinforcement, attention and...
10.
Pizzi M, Sarnico I, Boroni F, Benetti A, Benarese M, Spano P
Acta Neurochir Suppl
. 2005 Jul;
93:59-63.
PMID: 15986728
NF-kappaB is a nuclear transcription factor involved in the control of fundamental cellular functions including regulation of cell survival. We investigated NF-kappaB activation induced by two opposing modulators of cell...