P E Mirkes
Overview
Explore the profile of P E Mirkes including associated specialties, affiliations and a list of published articles.
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Articles
57
Citations
233
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Recent Articles
1.
Little S, Kim W, Mirkes P
Cell Biol Toxicol
. 2003 Dec;
19(4):215-26.
PMID: 14686614
Background: Previous work has shown that teratogens such as hyperthermia (HS), 4-hydroperoxycyclophosphamide (4CP), and staurosporine (ST) induce cell death in day 9 mouse embryos by activating the mitochondrial apoptotic pathway....
2.
Mirkes P, Little S, Umpierre C
Teratology
. 2001 Apr;
63(3):134-43.
PMID: 11283970
Background: Previous work has shown that caspase-3 activation and DNA fragmentation, two hallmarks of apoptosis, are induced in day 9 mouse embryos exposed to hyperthermia (43 degrees C); however, the...
3.
Mirkes P, Wilson K, Cornel L
Teratology
. 2000 Jun;
62(1):14-25.
PMID: 10861629
Background: Although many teratogens are known to activate apoptotic pathways culminating in abnormal development, little is known about how the embryo transduces a teratogenic exposure into specific responses. Signal reception...
4.
Mirkes P, Little S
Toxicol Appl Pharmacol
. 2000 Feb;
162(3):197-206.
PMID: 10652248
Cell death is an early and common event in the pathogenesis associated with the abnormal development induced by a variety of teratogens. Previously, we showed that the cell death induced...
5.
Mirkes P, Little S
Cell Death Differ
. 1999 Apr;
5(7):592-600.
PMID: 10200514
Teratogen-induced cell death is a common event in the pathogenesis associated with tissues destined to be malformed. Although the importance of this cell death is recognized, little information is available...
6.
Mirkes P, Cornel L, Wilson K, Dilmann W
Dev Dyn
. 1999 Feb;
214(2):159-70.
PMID: 10030595
Previous work has shown that there is a positive correlation between the induction of Hsp70 and its transient nuclear localization and the acquisition and loss of induced thermotolerance in postimplantation...
7.
Mirkes P
Mutat Res
. 1998 Jan;
396(1-2):163-73.
PMID: 9434867
Available data indicate that heat shock proteins act as chaperones under non-stress conditions by assisting in: (1) the folding of newly synthesized proteins, (2) the intracellular translocation of proteins, and...
8.
Mirkes P, Cornel L, Park H, Cunningham M
Teratology
. 1997 Nov;
56(3):210-9.
PMID: 9358608
Previously we reported that hyperthermia (43 degrees C) induces cell death in neurulation stage rat embryos as part of the pathogenesis culminating in abnormal growth and development. We now show...
9.
Bratton S, Jardine D, Mirkes P
Int J Hyperthermia
. 1997 Mar;
13(2):157-68.
PMID: 9147143
There is no clinical laboratory marker to enhance the diagnosis of recent thermal stress in humans. The 72 kD heat shock protein, HSP 72, which is rapidly synthesized after heat...
10.
THAYER J, Mirkes P
Dev Dyn
. 1997 Feb;
208(2):227-43.
PMID: 9022060
A number of cell culture studies have indicated that there is a positive correlation between the induction and decay of thermotolerance and the kinetics of Hsp72 expression. In this study,...