P D Darbre
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Explore the profile of P D Darbre including associated specialties, affiliations and a list of published articles.
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74
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789
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Recent Articles
11.
Shaw L, Sadler A, Pugazhendhi D, Darbre P
J Steroid Biochem Mol Biol
. 2006 Mar;
99(1):19-32.
PMID: 16533599
Cell culture models of antioestrogen resistance often involve applying selective pressures of oestrogen deprivation simultaneously with addition of tamoxifen or fulvestrant (Faslodex, ICI 182,780) which makes it difficult to distinguish...
12.
Darbre P
Best Pract Res Clin Endocrinol Metab
. 2006 Mar;
20(1):121-43.
PMID: 16522524
The established role of oestrogen in the development and progression of breast cancer raises questions concerning a potential contribution from the many chemicals in the environment which can enter the...
13.
Darbre P
J Appl Toxicol
. 2006 Feb;
26(3):191-7.
PMID: 16489580
Many compounds in the environment have been shown capable of binding to cellular oestrogen receptors and then mimicking the actions of physiological oestrogens. The widespread origin and diversity in chemical...
14.
Darbre P
J Inorg Biochem
. 2005 Jul;
99(9):1912-9.
PMID: 16045991
Aluminium salts are used as the active antiperspirant agent in underarm cosmetics, but the effects of widespread, long term and increasing use remain unknown, especially in relation to the breast,...
15.
Pugazhendhi D, Pope G, Darbre P
J Appl Toxicol
. 2005 Jul;
25(4):301-9.
PMID: 16021681
This paper addresses the question of whether p-hydroxybenzoic acid, the common metabolite of parabens, possesses oestrogenic activity in human breast cancer cell lines. The alkyl esters of p-hydroxybenzoic acid (parabens)...
16.
Matsumura A, Ghosh A, Pope G, Darbre P
J Steroid Biochem Mol Biol
. 2005 May;
94(5):431-43.
PMID: 15876408
Previous studies have compared the oestrogenic properties of phytoestrogens in a wide variety of disparate assays. Since not all phytoestrogens have been tested in each assay, this makes inter-study comparisons...
17.
18.
Darbre P, Aljarrah A, Miller W, Coldham N, Sauer M, Pope G
J Appl Toxicol
. 2004 Jan;
24(1):5-13.
PMID: 14745841
Parabens are used as preservatives in many thousands of cosmetic, food and pharmaceutical products to which the human population is exposed. Although recent reports of the oestrogenic properties of parabens...
19.
Darbre P
J Appl Toxicol
. 2003 Apr;
23(2):89-95.
PMID: 12666152
Although risk factors are known to include the loss of function of the susceptibility genes BRCA1/BRCA2 and lifetime exposure to oestrogen, the main causative agents in breast cancer remain unaccounted...
20.
Darbre P, Byford J, Shaw L, Hall S, Coldham N, Pope G, et al.
J Appl Toxicol
. 2003 Jan;
23(1):43-51.
PMID: 12518336
Previous work has demonstrated that the alkyl esters of p-hydroxybenzoic acid (parabens) possess oestrogenic activity, which increases with length of alkyl chain from methylparaben to n-butylparaben and with branching in...