P Chames
Overview
Explore the profile of P Chames including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
187
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Recent Articles
1.
Bouvin-Pley M, Morgand M, Meyer L, Goujard C, Moreau A, Mouquet H, et al.
J Virol
. 2014 Sep;
88(23):13910-7.
PMID: 25231299
Extending our previous analyses to the most recently described monoclonal broadly neutralizing antibodies (bNAbs), we confirmed a drift of HIV-1 clade B variants over 2 decades toward higher resistance to...
2.
Willemsen R, Debets R, Hart E, Hoogenboom H, Bolhuis R, Chames P
Gene Ther
. 2002 Mar;
8(21):1601-8.
PMID: 11894998
The clinical benefit of adoptive transfer of MHC-restricted cytotoxic T lymphocytes(CTL) for the treatment of cancer is hampered by the low success rate to generate antitumor CTLs. To bypass the...
3.
Willemsen R, Weijtens M, Ronteltap C, Eshhar Z, Gratama J, Chames P, et al.
Gene Ther
. 2000 Sep;
7(16):1369-77.
PMID: 10981663
Primary human activated T lymphocytes were genetically grafted with chimeric T cell receptors (TCR). Three domain single chain (sc-) TCR as well as two chain (tc-) TCR gene constructs were...
4.
Hoogenboom H, Chames P
Immunol Today
. 2000 Aug;
21(8):371-8.
PMID: 10916139
In the past decade, the drive to develop completely human antibodies for human therapy has led to the development of phage display technology. This technology is able to deliver the...
5.
Chames P, Baty D
FEMS Microbiol Lett
. 2000 Jul;
189(1):1-8.
PMID: 10913857
During the last decade, recombinant antibody engineering has emerged as one of the most promising approaches for the design, selection and production of molecules for basic research, medicine and the...
6.
Chames P, Hufton S, Coulie P, Uchanska-Ziegler B, Hoogenboom H
Proc Natl Acad Sci U S A
. 2000 Jul;
97(14):7969-74.
PMID: 10884427
Antitumor antibodies with the same specificity as cytotoxic T lymphocytes that recognize antigenic peptides encoded by tumor-associated genes and presented by MHC class I molecules would be valuable tools to...
7.
Chames P, Coulon S, Baty D
J Immunol
. 1998 Nov;
161(10):5421-9.
PMID: 9820517
Immunoassays are widely used to determine steroid concentrations. However, they are limited by the specificity of antisteroid mAbs. We used the phage display system combined with molecular modeling and site-specific...
8.
Chames P, Baty D
Clin Chem Lab Med
. 1998 Aug;
36(6):355-9.
PMID: 9711421
Immunoassays are widely used for determination of the concentration of steroid hormones. However, obtaining specific anti-steroid monoclonal antibodies remains difficult. We used antibody engineering and phage display methods to change...
9.
Chames P, Fieschi J, Baty D, Duche D
J Bacteriol
. 1998 Feb;
180(3):514-8.
PMID: 9457852
Intracellularly expressed antibodies have been designed to bind and inactivate target molecules inside eukaryotic cells. Here we report that an antibody fragment can be used to probe the periplasmic localization...
10.
Chames P, Fieschi J, Baty D
FEBS Lett
. 1997 Mar;
405(2):224-8.
PMID: 9089295
The 6D6 anti-cortisol scFv was prepared as fusion protein with maltose-binding protein (MBP) to increase the amount of soluble product. This fusion was almost completely insoluble when produced in a...