P B Dirks
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Explore the profile of P B Dirks including associated specialties, affiliations and a list of published articles.
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23
Citations
710
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Recent Articles
11.
Dirks P, Rutka J, Hubbard S, Mondal S, Hamel P
Oncogene
. 1998 Oct;
17(7):867-76.
PMID: 9780003
We previously demonstrated that P16Ink4a (p16) expression in p16-deficient U343 astrocytoma cells causes a G1 cell cycle arrest, profound changes in cytoskeletal proteins and alterations in expression and activity of...
12.
Rutka J, Ackerley C, Hubbard S, Tilup A, Dirks P, Jung S, et al.
Eur J Cell Biol
. 1998 Oct;
76(4):279-87.
PMID: 9765058
The role that glial filaments play in cells and tumors of glial origin is not well understood. We therefore undertook the present study to determine the relationships between glial and...
13.
Dirks P, Patel K, Hubbard S, Ackerley C, Hamel P, Rutka J
Oncogene
. 1997 Nov;
15(17):2037-48.
PMID: 9366521
We have characterized the expression and activity of the cell cycle regulatory machinery and the organization of the cytoskeleton of the p16(Ink4a)-deficient astrocytoma cell line, U343 MG-a (U343), following retinoic...
14.
Rutka J, Murakami M, Dirks P, Hubbard S, Becker L, Fukuyama K, et al.
J Neurosurg
. 1997 Sep;
87(3):420-30.
PMID: 9285609
In the adult human brain, normal astrocytes constitute nearly 40% of the total central nervous system (CNS) cell population and may assume a star-shaped configuration resembling epithelial cells insofar as...
15.
Dirks P, Rutka J
Neurosurgery
. 1997 May;
40(5):1000-13; discussion 1013-5.
PMID: 9149259
Uncontrolled cellular proliferation is the hallmark of human malignant brain tumors. Their growth proceeds inexorably, in part because their cellular constituents have an altered genetic code that enables them to...
16.
Dirks P, Hubbard S, Murakami M, Rutka J
J Neuropathol Exp Neurol
. 1997 Mar;
56(3):291-300.
PMID: 9056543
The expression of cyclins (A, B1, D1, D3, E), cyclin-dependent kinases (CDK2(3), CDK4), and the cyclin-dependent kinase inhibitors (CDKIs) p16(INK4A) and p21(CIP1) was studied in 9 malignant human astrocytoma cell...
17.
Murakami M, Fukuyama K, Hubbard S, Matsuzawa K, Dirks P, Rutka J
Cell Growth Differ
. 1996 Dec;
7(12):1697-703.
PMID: 8959338
Glial fibrillary acidic protein (GFAP) is an intermediate filament protein expressed almost exclusively by glial cells of the central nervous system. We have previously transfected GFAP-negative human astrocytoma cells with...
18.
Matsuzawa K, Fukuyama K, Dirks P, Hubbard S, Murakami M, Becker L, et al.
J Neurooncol
. 1996 Dec;
30(3):181-8.
PMID: 8943093
In a wide variety of tumor types, the expression of stromelysin 1 which is one of the matrix metalloproteinases (MMPs) has been shown to correlate with tumor invasion. However, little...
19.
Dirks P, Harris L, Hoffman H, Humphreys R, Drake J, Rutka J
J Neurooncol
. 1996 Jul;
29(1):75-84.
PMID: 8817418
A retrospective review of 36 children diagnosed with a supratentorial primitive neuroectodermal tumor (PNET) at the Hospital for Sick Children was performed for the period 1970-1995. All children but one...
20.
Fukuyama K, Matsuzawa K, Hubbard S, Dirks P, Murakami M, Rutka J
Anticancer Res
. 1996 May;
16(3A):1251-7.
PMID: 8702246
Glial fibrillary acidic protein (GFAP) is an intermediate filament specifically expressed in glial cells which helps to maintain and stabilize the glial cytoskeleton. Interestingly, with increasing astrocytic anaplasia, there is...