P A Ferchmin
Overview
Explore the profile of P A Ferchmin including associated specialties, affiliations and a list of published articles.
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45
Citations
327
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Recent Articles
1.
Rivera-Garcia L, Francis-Malave A, Castillo Z, Uong C, Wilson T, Ferchmin P, et al.
J Inflamm (Lond)
. 2024 Jan;
21(1):2.
PMID: 38267952
4R is a tobacco cembranoid that binds to and modulates cholinergic receptors and exhibits neuroprotective and anti-inflammatory activity. Given the established function of the cholinergic system in pain and inflammation,...
2.
Ferrer-Acosta Y, Rodriguez-Masso S, Perez D, Eterovic V, Ferchmin P, Martins A
Toxicol In Vitro
. 2022 Aug;
84:105453.
PMID: 35944748
Memantine is a non-competitive antagonist with a moderate affinity to the N-methyl-d-Aspartate (NMDA) receptor. The present study assessed memantine's neuroprotective activity using electrophysiology of ex-vivo hippocampal slices. Interestingly, a nicotinic...
3.
Hu J, Ferchmin P, Hemmerle A, Seroogy K, Eterovic V, Hao J
Front Neurosci
. 2017 Jun;
11:272.
PMID: 28611572
(1S, 2E, 4R, 6R,-7E, 11E)-2, 7, 11-cembratriene-4, 6-diol (4R) is one of the cembranoids found in tobacco leaves. Previous studies have found that 4R protected acute rat hippocampal slices against...
4.
Ferchmin P, Perez D, Cuadrado B, Carrasco M, Martins A, Eterovic V
Neurochem Res
. 2015 Oct;
40(10):2143-51.
PMID: 26438150
Diisopropylfluorophosphate (DFP) is an irreversible inhibitor of acetylcholine esterase and a surrogate of the organophosphorus (OP) nerve agent sarin. The neurotoxicity of DFP was assessed as a reduction of population...
5.
Velez-Carrasco W, Green C, Catz P, Furimsky A, OLoughlin K, Eterovic V, et al.
PLoS One
. 2015 Mar;
10(3):e0121540.
PMID: 25811857
4R-cembranoid (4R) is a natural cyclic diterpenoid found in tobacco leaves that displays neuroprotective activity. 4R protects against NMDA, paraoxon (POX), and diisopropylfluorophosphate (DFP) damage in rat hippocampal slices and...
6.
Berrios V, Boukli N, Rodriguez J, Negraes P, Schwindt T, Trujillo C, et al.
Neurochem Res
. 2015 Mar;
40(10):2091-101.
PMID: 25758980
Acetylcholinesterase (AChE) inhibition has been described as the main mechanism of organophosphate (OP)-evoked toxicity. OPs represent a human health threat, because chronic exposure to low doses can damage the developing...
7.
Ferchmin P, Andino M, Reyes Salaman R, Alves J, Velez-Roman J, Cuadrado B, et al.
Neurotoxicology
. 2014 Jun;
44:80-90.
PMID: 24928201
Many organophosphorous esters synthesized for applications in industry, agriculture, or warfare irreversibly inhibit acetylcholinesterase, and acute poisoning with these compounds causes life-threatening cholinergic overstimulation. Following classical emergency treatment with atropine,...
8.
Torres-Rivera W, Perez D, Park K, Carrasco M, Platt M, Eterovic V, et al.
Neuroscience
. 2013 Jun;
247:273-9.
PMID: 23735753
The kinin-B2 receptor (B2BKR) activated by its endogenous ligand bradykinin participates in various metabolic processes including the control of arterial pressure and inflammation. Recently, functions for this receptor in brain...
9.
Ferchmin P, Perez D, Castro Alvarez W, Penzo M, Maldonado H, Eterovic V
J Neurosci Res
. 2013 Jan;
91(3):416-25.
PMID: 23280428
Nicotinic acetylcholine receptor (nAChR)-mediated neuroprotection has been implicated in the treatment of neurodegenerative disorders such as Alzheimer's and Parkinson's diseases and hypoxic ischemic events as well as other diseases hallmarked...
10.
Eterovic V, Perez D, Martins A, Cuadrado B, Carrasco M, Ferchmin P
Toxicol In Vitro
. 2011 May;
25(7):1468-74.
PMID: 21569834
Many neurotoxic organophosphates (OPs) inhibit acetylcholinesterase (AChE) and as a result can cause a life threatening cholinergic crisis. Current medical countermeasures, which typically include atropine and oximes target the cholinergic...