Otilia Obreja
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Explore the profile of Otilia Obreja including associated specialties, affiliations and a list of published articles.
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Articles
28
Citations
639
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Recent Articles
1.
Werland F, de Col R, Hirth M, Turnquist B, Schmelz M, Obreja O
Pain
. 2021 Jan;
162(7):2002-2013.
PMID: 33449511
Ultraviolet B (UVB) irradiation induces hyperalgesia in human and animal pain models. We investigated mechanical sensitization, increase in axonal excitability, and spontaneous activity in different C-nociceptor classes after UVB in...
2.
Werland F, Hirth M, Rukwied R, Ringkamp M, Turnquist B, Jorum E, et al.
J Physiol
. 2020 Dec;
599(5):1595-1610.
PMID: 33369733
Key Points: C-nociceptors are generally assumed to have a low maximum discharge frequency of 10-30 Hz. However, only mechano-insensitive 'silent' C-nociceptors cannot follow electrical stimulation at 5 Hz (75 pulses)...
3.
Rukwied R, Thomas C, Obreja O, Werland F, Kleggetveit I, Jorum E, et al.
Pain
. 2020 May;
161(9):2119-2128.
PMID: 32379219
High-threshold mechanosensitive and mechanoinsensitive ("silent") nociceptors have similar electrical thresholds for transcutaneous sine wave stimulation at 4 Hz that selectively activates cutaneous C nociceptors in human skin. Their fundamentally different...
4.
Jonas R, Prato V, Lechner S, Groen G, Obreja O, Werland F, et al.
Front Cell Neurosci
. 2020 Mar;
14:13.
PMID: 32116559
Pronounced activity-dependent slowing of conduction has been used to characterize mechano-insensitive, "silent" nociceptors and might be due to high expression of Na1.8 and could, therefore, be characterized by their tetrodotoxin-resistance...
5.
Obreja O, Rukwied R, Nagler L, Schmidt M, Schmelz M, Namer B
Pain
. 2017 Nov;
159(3):416-426.
PMID: 29140928
Nerve growth factor (NGF) injected into the human skin causes local hyperalgesia to mechanical and electrical stimuli lasting for weeks. Pig data suggested axonal sensitization of C-nociceptors as a contributing...
6.
Achtnichts L, Obreja O, Conen A, Fux C, Nedeltchev K
JAMA Neurol
. 2015 Oct;
72(10):1203-5.
PMID: 26457631
No abstract available.
7.
Tigerholm J, Petersson M, Obreja O, Eberhardt E, Namer B, Weidner C, et al.
Biophys J
. 2015 Mar;
108(5):1057-71.
PMID: 25762318
Following each action potential, C-fiber nociceptors undergo cyclical changes in excitability, including a period of superexcitability, before recovering their basal excitability state. The increase in superexcitability during this recovery cycle...
8.
Weinkauf B, Deising S, Obreja O, Hoheisel U, Mense S, Schmelz M, et al.
Muscle Nerve
. 2014 Dec;
52(2):265-72.
PMID: 25521275
Introduction: Nerve growth factor (NGF) induces profound hyperalgesia. In this study we explored patterns of NGF sensitization in muscle and fascia of distal and paraspinal sites. Methods: We injected 1...
9.
Petersson M, Obreja O, Lampert A, Carr R, Schmelz M, Fransen E
PLoS One
. 2014 Aug;
9(8):e103556.
PMID: 25136824
Cutaneous pain sensations are mediated largely by C-nociceptors consisting of both mechano-sensitive (CM) and mechano-insensitive (CMi) fibres that can be distinguished from one another according to their characteristic axonal properties....
10.
Tigerholm J, Petersson M, Obreja O, Lampert A, Carr R, Schmelz M, et al.
J Neurophysiol
. 2013 Dec;
111(9):1721-35.
PMID: 24371290
Action potential initiation and conduction along peripheral axons is a dynamic process that displays pronounced activity dependence. In patients with neuropathic pain, differences in the modulation of axonal conduction velocity...