Osamu Shimozato
Overview
Explore the profile of Osamu Shimozato including associated specialties, affiliations and a list of published articles.
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Articles
45
Citations
503
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Recent Articles
21.
Nagakawa H, Shimozato O, Yu L, Wada A, Kawamura K, Li Q, et al.
Cell Immunol
. 2012 Apr;
275(1-2):90-7.
PMID: 22475191
Expression of human interleukin (IL)-24 in tumors achieved anti-tumor effects through apoptosis. IL-24 also induced secretion of proinflammatory cytokines, suggesting the role in immunity. We showed that murine IL-24 transcripts...
22.
Kawamura T, Ogawa Y, Shimozato O, Ando T, Nakao A, Kobata T, et al.
J Invest Dermatol
. 2011 Apr;
131(6):1252-61.
PMID: 21490618
The interaction between CD27 and CD70 provides a costimulatory signal for T-cell survival. Although the role of CD27 signaling in CD8(+) T cells has been well defined, its role in...
23.
Okoshi R, Kubo N, Nakashima K, Shimozato O, Nakagawara A, Ozaki T
Biochem Biophys Res Commun
. 2011 Feb;
406(1):79-84.
PMID: 21295542
Recently, we have described that CREB (cAMP-responsive element-binding protein) has the ability to transactivate tumor suppressor p53 gene in response to glucose deprivation. In this study, we have found that...
24.
Kimura M, Takenobu H, Akita N, Nakazawa A, Ochiai H, Shimozato O, et al.
Cancer Sci
. 2011 Feb;
102(5):983-90.
PMID: 21276135
Mortality from lung cancer is important worldwide. Recently, epigenetic aberration of lung cancer, not only genomic DNA methylation but also chromatin modification, has become an important target for lung cancer...
25.
Kubo N, Okoshi R, Nakashima K, Shimozato O, Nakagawara A, Ozaki T
Biochem Biophys Res Commun
. 2010 Nov;
403(3-4):405-11.
PMID: 21093410
It has been shown that MDM2 inhibits the transcriptional and pro-apoptotic activities of p73 but does not promote its proteasomal degradation. In this study, we found that MDM2 indirectly induces...
26.
Shimozato O, Sato A, Kawamura K, Chiyo M, Ma G, Li Q, et al.
Immunology
. 2009 Sep;
128(1 Suppl):e816-25.
PMID: 19740343
Interleukin-27 (IL-27) is a new IL-12-related heterodimeric cytokine comprising a novel p28 molecule and the Epstein-Barr-virus-induced gene 3 (EBI3) molecules. It augments initiation of T helper type 1-mediated immunity by...
27.
Sang M, Ando K, Okoshi R, Koida N, Li Y, Zhu Y, et al.
Genes Cells
. 2009 Jun;
14(7):775-88.
PMID: 19490146
Plk3, one of Polo-like kinase family members, is involved in the regulation of cell cycle progression and DNA damage response. In this study, we found that Plk3 inhibits pro-apoptotic activity...
28.
Yu L, Shimozato O, Li Q, Kawamura K, Ma G, Namba M, et al.
Anticancer Res
. 2007 Aug;
27(4B):2311-6.
PMID: 17695519
Infectivity of adenovirus type 5 (Ad5) to cells depends primarily on its fiber-mediated binding to the coxsackievirus and adenovirus receptor (CAR) on target cells. Down-regulated CAR expression, often found in...
29.
Kawamura K, Yu L, Tomizawa M, Shimozato O, Ma G, Li Q, et al.
Anticancer Res
. 2007 Mar;
27(1A):89-93.
PMID: 17352220
Selective expression of a therapeutic gene in tumors contributes to the efficacy and the safety of cancer therapy. Regulatory regions of genes that are preferentially expressed in tumors have been...
30.
Tagawa M, Kawamura K, Shimozato O, Ma G, Li Q, Suzuki N, et al.
Cancer Immunol Immunother
. 2006 May;
55(11):1420-5.
PMID: 16691360
Current strategies for cancer gene therapy consist mainly of direct inhibition of tumor cell growth and activation of systemic host defense mechanisms. Conventional chemotherapy and radiotherapy, even considered to be...