Osamu Hazeki
Overview
Explore the profile of Osamu Hazeki including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
534
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Recent Articles
1.
Morioka S, Nigorikawa K, Hazeki K, Ohmura M, Sakamoto H, Matsumura T, et al.
Exp Cell Res
. 2017 May;
357(2):252-259.
PMID: 28552585
The findings of this study suggest that the phosphoinositide phosphatase Sac3 maintains the protein level of scavenger receptor A (SR-A) and regulates foam cell formation. RAW264.7 macrophages were transfected with...
2.
Segawa T, Hazeki K, Nigorikawa K, Nukuda A, Tanizawa T, Miyamoto K, et al.
Innate Immun
. 2017 Apr;
23(4):401-409.
PMID: 28409542
The relative abundance of phosphoinositide (PI) species on the phagosome membrane fluctuates over the course of phagocytosis. PtdIns(3,4,5)P and PtdIns(3,4)P rapidly increase in the forming of the phagocytic cup, following...
3.
Morioka S, Nigorikawa K, Sasaki J, Hazeki K, Kasuu Y, Sasaki T, et al.
Innate Immun
. 2016 Jun;
22(6):444-51.
PMID: 27252170
Phosphatidylinositol 3-kinase (PI3K)/Akt signaling has been implicated in the anti-inflammatory response in a mouse model of endotoxemia and sepsis. The present study focused on the role of inositol polyphosphate-4-phosphatase type...
4.
Nigorikawa K, Hazeki K, Sasaki J, Omori Y, Miyake M, Morioka S, et al.
PLoS One
. 2015 Nov;
10(11):e0142091.
PMID: 26535897
Phagocytosis is a highly conserved process whereby phagocytic cells engulf pathogens and apoptotic bodies. The present study focused on the role of inositol polyphosphate-4-phosphatase type I (Inpp4a) in phagocytosis. Raw264.7...
5.
Nigorikawa K, Hazeki K, Guo Y, Hazeki O
PLoS One
. 2014 Oct;
9(10):e111698.
PMID: 25357130
In this study, we present findings that suggest that PI3K-C2α, a member of the class II phosphoinositide 3-kinase (PI3K) subfamily, regulates the process of FcεRI-triggered degranulation. RBL-2H3 cells were transfected...
6.
Segawa T, Hazeki K, Nigorikawa K, Morioka S, Guo Y, Takasuga S, et al.
Biochem J
. 2014 Oct;
464(3):365-75.
PMID: 25269936
Phosphoinositide 5'-phosphatases have been implicated in the regulation of phagocytosis. However, their precise roles in the phagocytic process are poorly understood. We prepared RAW264.7 macrophages deficient in Inpp5e (shInpp5e) to...
7.
Hazeki K, Uehara M, Nigorikawa K, Hazeki O
PLoS One
. 2013 Sep;
8(9):e73894.
PMID: 24040108
TLR9 is a receptor for oligodeoxynucleotides that contain unmethylated CpG motifs (CpG). Because TLR9 resides in the endoplasmic reticulum during the quiescence state, CpG binding to TLR9 requires membrane trafficking,...
8.
Nigorikawa K, Hazeki K, Kumazawa T, Itoh Y, Hoshi M, Hazeki O
J Pharmacol Sci
. 2012 Nov;
120(4):270-9.
PMID: 23149576
Studies with knockout mice have indicated that the only isoform of phosphoinositide 3-kinase (PI3K) functioning in the oxidative burst of mouse neutrophils in response to heterotrimeric guanine nucleotide-binding protein-coupled receptor...
9.
Hazeki K, Nigorikawa K, Takaba Y, Segawa T, Nukuda A, Masuda A, et al.
FEBS Lett
. 2012 Oct;
586(22):4010-5.
PMID: 23068606
PtdIns(3)P (phosphatidylinositol 3-phosphate) is a signaling molecule important for phagosome maturation. The major role of Vps34 in production of phagosomal PtdIns(3)P has been indicated. However, the fate of the newly...
10.
Hazeki K, Kametani Y, Murakami H, Uehara M, Ishikawa Y, Nigorikawa K, et al.
PLoS One
. 2011 Nov;
6(10):e26836.
PMID: 22053215
Synthetic oligodeoxynucleotides containing unmethylated CpG motifs (CpG) stimulate innate immune responses. Phosphoinositide 3-kinase (PI3K) has been implicated in CpG-induced immune activation; however, its precise role has not yet been clarified....