Olof Sigurdardottir
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Explore the profile of Olof Sigurdardottir including associated specialties, affiliations and a list of published articles.
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33
Citations
1675
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Recent Articles
1.
Kristjansdottir K, Norddahl G, Ivarsdottir E, Halldorsson G, Einarsson G, Bjarnadottir K, et al.
J Allergy Clin Immunol
. 2024 Oct;
155(1):228-235.
PMID: 39423878
Background: Signal transducer and activator of transcription 6 (STAT6) is central to type 2 (T2) inflammation, and common noncoding variants at the STAT6 locus associate with various T2 inflammatory traits,...
2.
Olafsdottir T, Thorleifsson G, Lopez de Lapuente Portilla A, Jonsson S, Stefansdottir L, Niroula A, et al.
Nat Commun
. 2024 Sep;
15(1):8054.
PMID: 39277589
Immunoglobulin G (IgG) is the main isotype of antibody in human blood. IgG consists of four subclasses (IgG1 to IgG4), encoded by separate constant region genes within the Ig heavy...
3.
Oskarsson G, Magnusson M, Oddsson A, Jensson B, Fridriksdottir R, Arnadottir G, et al.
Commun Biol
. 2022 Jun;
5(1):525.
PMID: 35650273
The characteristic lobulated nuclear morphology of granulocytes is partially determined by composition of nuclear envelope proteins. Abnormal nuclear morphology is primarily observed as an increased number of hypolobulated immature neutrophils,...
4.
Mikaelsdottir E, Thorleifsson G, Stefansdottir L, Halldorsson G, Sigurdsson J, Lund S, et al.
Commun Biol
. 2021 Sep;
4(1):1132.
PMID: 34580418
Platelets play an important role in hemostasis and other aspects of vascular biology. We conducted a meta-analysis of platelet count GWAS using data on 536,974 Europeans and identified 577 independent...
5.
Bjornsson E, Thorgeirsson G, Helgadottir A, Thorleifsson G, Sveinbjornsson G, Kristmundsdottir S, et al.
Arterioscler Thromb Vasc Biol
. 2021 Aug;
41(10):2616-2628.
PMID: 34407635
Objective: Familial hypercholesterolemia (FH) is traditionally defined as a monogenic disease characterized by severely elevated LDL-C (low-density lipoprotein cholesterol) levels. In practice, FH is commonly a clinical diagnosis without confirmation...
6.
Beyter D, Ingimundardottir H, Oddsson A, Eggertsson H, Bjornsson E, Jonsson H, et al.
Nat Genet
. 2021 May;
53(6):779-786.
PMID: 33972781
Long-read sequencing (LRS) promises to improve the characterization of structural variants (SVs). We generated LRS data from 3,622 Icelanders and identified a median of 22,636 SVs per individual (a median...
7.
Bell S, Rigas A, Magnusson M, Ferkingstad E, Allara E, Bjornsdottir G, et al.
Commun Biol
. 2021 Feb;
4(1):156.
PMID: 33536631
Iron is essential for many biological functions and iron deficiency and overload have major health implications. We performed a meta-analysis of three genome-wide association studies from Iceland, the UK and...
8.
Bjornsson E, Gunnarsdottir K, Halldorsson G, Sigurdsson A, Arnadottir G, Jonsson H, et al.
Circ Genom Precis Med
. 2020 Dec;
14(1):e003029.
PMID: 33315477
Background: Loss-of-function mutations in the LDL (low-density lipoprotein) receptor gene () cause elevated levels of LDL cholesterol and premature cardiovascular disease. To date, a gain-of-function mutation in with a large...
9.
Genetic variability in the absorption of dietary sterols affects the risk of coronary artery disease
Helgadottir A, Thorleifsson G, Alexandersson K, Tragante V, Thorsteinsdottir M, Eiriksson F, et al.
Eur Heart J
. 2020 Jul;
41(28):2618-2628.
PMID: 32702746
Aims: To explore whether variability in dietary cholesterol and phytosterol absorption impacts the risk of coronary artery disease (CAD) using as instruments sequence variants in the ABCG5/8 genes, key regulators...
10.
Olafsdottir T, Theodors F, Bjarnadottir K, Bjornsdottir U, Agustsdottir A, Stefansson O, et al.
Nat Commun
. 2020 Jan;
11(1):393.
PMID: 31959851
Asthma is one of the most common chronic diseases affecting both children and adults. We report a genome-wide association meta-analysis of 69,189 cases and 702,199 controls from Iceland and UK...