Oliver Kohlbacher
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Explore the profile of Oliver Kohlbacher including associated specialties, affiliations and a list of published articles.
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246
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9025
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Recent Articles
1.
DAltri T, Freeberg M, Curwin A, Alonso A, Freitas A, Capella-Gutierrez S, et al.
Nat Genet
. 2025 Mar;
57(3):481-485.
PMID: 40033058
No abstract available.
2.
Cysteine-Directed Isobaric Labeling Combined with GeLC-FAIMS-MS for Quantitative Top-Down Proteomics
Matzanke T, Kaulich P, Jeong K, Takemori A, Takemori N, Kohlbacher O, et al.
J Proteome Res
. 2025 Jan;
24(3):1470-1480.
PMID: 39885717
The quantification of proteoforms, i.e., all molecular forms in which proteins can be present, by top-down proteomics provides essential insights into biological processes at the molecular level. Isobaric labeling-based quantification...
3.
Vetter J, Lim K, Dijkstra T, Dargaville P, Kohlbacher O, Macke J, et al.
PLOS Digit Health
. 2024 Dec;
3(12):e0000678.
PMID: 39671454
Neonatal apneas and hypopneas present a serious risk for healthy infant development. Treating these adverse events requires frequent manual stimulation by skilled personnel, which can lead to alarm fatigue. This...
4.
Varghese J, Schuster A, Poschkamp B, Yildirim K, Oehm J, Berens P, et al.
JMIR Med Inform
. 2024 Dec;
12:e60851.
PMID: 39637381
The EyeMatics project, embedded as a clinical use case in Germany's Medical Informatics Initiative, is a large digital health initiative in ophthalmology. The objective is to improve the understanding of...
5.
Holtrup L, Varghese J, Schuster A, Poschkamp B, Hampf C, Waltemath D, et al.
Ophthalmologie
. 2024 Nov;
PMID: 39542916
The evaluation of real-world data (RWD) enables insights to be gained from a wide range of patient data collected in routine clinical practice. In addition, multicenter analyses represent a broad...
6.
Kaulich P, Jeong K, Kohlbacher O, Tholey A
Nat Methods
. 2024 Oct;
21(12):2397-2407.
PMID: 39438734
Top-down proteomics using mass spectrometry facilitates the identification of intact proteoforms, that is, all molecular forms of proteins. Multiple past advances have lead to the development of numerous sample preparation...
7.
Kim J, Jeong K, Kaulich P, Winkels K, Tholey A, Kohlbacher O
Anal Chem
. 2024 Oct;
96(43):17227-17234.
PMID: 39424290
Accurate quantification of individual proteoforms is a crucial step in identifying proteome-wide alterations in different biological conditions. Intact proteoforms have been analyzed predominantly by liquid chromatography-mass spectrometry (LC-MS)-based top-down proteomics...
8.
Welp L, Sachsenberg T, Wulf A, Chernev A, Horokhovskyi Y, Neumann P, et al.
bioRxiv
. 2024 Sep;
PMID: 39257782
UV (ultra-violet) crosslinking with mass spectrometry (XL-MS) has been established for identifying RNA-and DNA-binding proteins along with their domains and amino acids involved. Here, we explore chemical XL-MS for RNA-protein,...
9.
Hirth A, Fatti E, Netz E, Acebron S, Papageorgiou D, Svorinic A, et al.
Genome Res
. 2024 Jul;
34(6):952-966.
PMID: 38986579
DEAD box (DDX) RNA helicases are a large family of ATPases, many of which have unknown functions. There is emerging evidence that besides their role in RNA biology, DDX proteins...
10.
Dai C, Pfeuffer J, Wang H, Zheng P, Kall L, Sachsenberg T, et al.
Nat Methods
. 2024 Jul;
21(9):1603-1607.
PMID: 38965444
The volume of public proteomics data is rapidly increasing, causing a computational challenge for large-scale reanalysis. Here, we introduce quantms ( https://quant,ms.org/ ), an open-source cloud-based pipeline for massively parallel...