Oliver H Wittekindt
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Explore the profile of Oliver H Wittekindt including associated specialties, affiliations and a list of published articles.
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31
Citations
574
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Recent Articles
1.
Schmidt H, Guthjahr L, Sauter A, Zech F, Nchioua R, Stenger S, et al.
Am J Physiol Cell Physiol
. 2022 Feb;
322(4):C591-C604.
PMID: 35196166
Primary airway epithelial cells (pAECs) cultivated at air-liquid interface (ALI) conditions are widely used as surrogates for human in vivo epithelia. To extend the proliferative capacity and to enable serially...
2.
Schilpp C, Lochbaum R, Braubach P, Jonigk D, Frick M, Dietl P, et al.
Pflugers Arch
. 2021 Jan;
473(2):287-311.
PMID: 33386991
TGF-β1 is a major mediator of airway tissue remodelling during atopic asthma and affects tight junctions (TJs) of airway epithelia. However, its impact on TJs of ciliated epithelia is sparsely...
3.
Lochbaum R, Schilpp C, Nonnenmacher L, Frick M, Dietl P, Wittekindt O
Cell Signal
. 2019 Sep;
65:109421.
PMID: 31536749
The pulmonary epithelium separates the gaseous intraluminal space of the airways and the aqueous interstitium. This compartimentalization is required for appropriate lung function, it is established during perinatal periods and...
4.
Schmidt H, Braubach P, Schilpp C, Lochbaum R, Neuland K, Thompson K, et al.
Int J Mol Sci
. 2019 Jul;
20(13).
PMID: 31262043
Interleukin-13 (IL-13) drives symptoms in asthma with high levels of T-helper type 2 cells (T2-cells). Since tight junctions (TJ) constitute the epithelial diffusion barrier, we investigated the effect of IL-13...
5.
Wittekindt O
Am J Respir Cell Mol Biol
. 2019 Apr;
61(4):410-411.
PMID: 30990760
No abstract available.
6.
Maerz L, Burkhalter M, Schilpp C, Wittekindt O, Frick M, Philipp M
Commun Biol
. 2019 Feb;
2:31.
PMID: 30729178
Patients with an inherited inability to synthesize sufficient amounts of cholesterol develop congenital malformations of the skull, toes, kidney and heart. As development of these structures depends on functional cilia...
7.
Wittekindt O, Dietl P
Pflugers Arch
. 2018 Nov;
471(4):519-532.
PMID: 30397774
The lung is the interface between air and blood where the exchange of oxygen and carbon dioxide occurs. The surface liquid that is directly exposed to the gaseous compartment covers...
8.
Winkelmann V, Thompson K, Neuland K, Jaramillo A, Fois G, Schmidt H, et al.
Am J Physiol Lung Cell Mol Physiol
. 2018 Oct;
316(1):L58-L70.
PMID: 30358443
Mucus clearance provides an essential innate defense mechanism to keep the airways and lungs free of particles and pathogens. Baseline and stimulated mucin secretion from secretory airway epithelial cells need...
9.
Fois G, Fohr K, Kling C, Fauler M, Wittekindt O, Dietl P, et al.
J Physiol
. 2018 Aug;
596(20):4893-4907.
PMID: 30144063
Re-sensitization of P2X receptors depends on a protonation/de-protonation cycle Protonation and de-protonation of the receptors is achieved by internalization and recycling of P2X receptors via acidic compartments Protonation and de-protonation...
10.
Wittekindt O
Pflugers Arch
. 2016 Dec;
469(1):135-147.
PMID: 27921210
Inflammatory lung diseases like asthma bronchiale, chronic obstructive pulmonary disease and allergic airway inflammation are widespread public diseases that constitute an enormous burden to the health systems. Mainly classified as...