Oliver Germershaus
Overview
Explore the profile of Oliver Germershaus including associated specialties, affiliations and a list of published articles.
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Articles
39
Citations
452
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0
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Recent Articles
1.
Ali D, S Pelaez S, Lemazurier T, Schroeter A, Adler M, Bong J, et al.
Eur J Pharm Biopharm
. 2024 Dec;
207:114618.
PMID: 39719255
Aseptic filling of biopharmaceutical products requires a grade A cleanroom environment, preferably ensured by isolators in grade C surroundings. Isolators are decontaminated before the start of filling processes using vaporized...
2.
Amara I, Germershaus O, Lentes C, Sass S, Youmto S, Stracke J, et al.
J Pharm Sci
. 2024 Apr;
113(8):2394-2404.
PMID: 38615817
Innovative analytical instruments and development of new methods has provided a better understanding of protein particle formation in biopharmaceuticals but have also challenged the ability to obtain reproducible and reliable...
3.
Gregoritza K, Theodorou C, Heitz M, Graf T, Germershaus O, Gregoritza M
Eur J Pharm Biopharm
. 2023 Dec;
194:74-84.
PMID: 38042510
Polysorbate 20 (PS20) is widely used to maintain protein stability in biopharmaceutical formulations. However, PS20 is susceptible to hydrolytic degradation catalyzed by trace amounts of residual host cell proteins present...
4.
Brosig S, Cucuzza S, Serno T, Bechtold-Peters K, Buecheler J, Zivec M, et al.
ACS Appl Mater Interfaces
. 2023 Jul;
15(29):34540-34553.
PMID: 37450418
Therapeutically relevant proteins naturally adsorb to interfaces, causing aggregation which in turn potentially leads to numerous adverse consequences such as loss of activity or unwanted immunogenic reactions. Surfactants are ubiquitously...
5.
Li L, Qian Y, Lin C, Li H, Jiang C, Lv Y, et al.
J Mater Chem B
. 2020 Apr;
3(5):859-870.
PMID: 32262177
The application of silk fibroin is a promising approach for designing biomaterials. However, silk sericin (SS) protein has not attracted much attention in the field of biomaterials as a natural...
6.
Koch F, Ekat K, Kilian D, Hettich T, Germershaus O, Lang H, et al.
Adv Healthc Mater
. 2019 Apr;
8(13):e1900167.
PMID: 30985084
Periodontitis is a chronic inflammatory and tissue-destructive disease. Since the polymicrobiome in the oral cavity makes it difficult to treat, novel therapeutic strategies are required. Hydrogels based on self-assembling peptides...
7.
S Pelaez S, Mahler H, Herdlitschka C, Wertli T, Kahl M, Koulov A, et al.
PDA J Pharm Sci Technol
. 2019 Jan;
73(3):220-234.
PMID: 30651337
The sterility of drug products intended for parenteral administration is a critical quality attribute (CQA) because it serves to ensure patient safety and is thus a key requirement by health...
8.
Nultsch K, Germershaus O
Eur J Pharm Biopharm
. 2018 Aug;
131:189-202.
PMID: 30145219
Engineering of drug delivery systems has evolved in recent decades from comparably simple designs that merely controlled drug release to complex, often multistage systems that respond to multiple biological or...
9.
S Pelaez S, Mahler H, Matter A, Koulov A, Singh S, Germershaus O, et al.
J Pharm Sci
. 2018 Apr;
107(8):2091-2097.
PMID: 29626532
Prefilled syringes (PFSs) are increasingly preferred over vials as container closure systems (CCSs) for injectable drug products when facilitated or self-administration is required. However, PFSs are more complex compared to...
10.
Qian Y, Li L, Song Y, Dong L, Chen P, Li X, et al.
Biomaterials
. 2018 Feb;
164:22-37.
PMID: 29482061
The inherent hydrophobicity and large surface area of electrospun synthetic polymeric scaffolds often cause non-specific protein adsorption, thereby influencing macrophage functions and eventually leading to fibrosis at the tissue-scaffold interface....