Oleg Butovsky
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Explore the profile of Oleg Butovsky including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
McKinsey G, Santander N, Zhang X, Kleemann K, Tran L, Katewa A, et al.
bioRxiv
. 2023 Oct;
PMID: 37790363
Microglia diversity emerges from interactions between intrinsic genetic programs and environment-derived signals, but how these processes unfold and interact in the developing brain remains unclear. Here, we show that radial...
12.
Yin Z, Rosenzweig N, Kleemann K, Zhang X, Brandao W, Margeta M, et al.
Nat Immunol
. 2023 Sep;
24(11):1839-1853.
PMID: 37749326
The APOE4 allele is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). The contribution of microglial APOE4 to AD pathogenesis is unknown, although APOE has the most enriched...
13.
Lopes J, Zhang X, Mayrink J, Tatematsu B, Guo L, S LeServe D, et al.
Proc Natl Acad Sci U S A
. 2023 Sep;
120(37):e2309221120.
PMID: 37669383
Emerging evidence suggests that dysregulation of neuroinflammation, particularly that orchestrated by microglia, plays a significant role in the pathogenesis of Alzheimer's disease (AD). Danger signals including dead neurons, dystrophic axons,...
14.
Abou-El-Hassan H, Rezende R, Izzy S, Gabriely G, Yahya T, Tatematsu B, et al.
Nat Commun
. 2023 Jul;
14(1):4286.
PMID: 37463881
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality. The innate and adaptive immune responses play an important role in the pathogenesis of TBI. Gamma-delta (γδ) T...
15.
Yin Z, Herron S, Silveira S, Kleemann K, Gauthier C, Mallah D, et al.
Nat Neurosci
. 2023 Jun;
26(7):1196-1207.
PMID: 37291336
Microglia play a critical role in brain homeostasis and disease progression. In neurodegenerative conditions, microglia acquire the neurodegenerative phenotype (MGnD), whose function is poorly understood. MicroRNA-155 (miR-155), enriched in immune...
16.
Guneykaya D, Ugursu B, Logiacco F, Popp O, Feiks M, Meyer N, et al.
Brain Behav Immun
. 2023 Mar;
111:61-75.
PMID: 37001827
Neuroligin-4 (NLGN4) loss-of-function mutations are associated with monogenic heritable autism spectrum disorder (ASD) and cause alterations in both synaptic and behavioral phenotypes. Microglia, the resident CNS macrophages, are implicated in...
17.
Paolicelli R, Sierra A, Stevens B, Tremblay M, Aguzzi A, Ajami B, et al.
Neuron
. 2022 Nov;
110(21):3458-3483.
PMID: 36327895
Microglial research has advanced considerably in recent decades yet has been constrained by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." This dualistic classification...
18.
Shi H, Yin Z, Koronyo Y, Fuchs D, Sheyn J, Davis M, et al.
Acta Neuropathol Commun
. 2022 Sep;
10(1):136.
PMID: 36076283
Single cell RNA sequencing studies identified novel neurodegeneration-associated microglial (MGnD/DAM) subtypes activated around cerebral amyloid plaques. Micro-RNA (miR)-155 of the TREM2-APOE pathway was shown to be a key transcriptional regulator...
19.
Margeta M, Yin Z, Madore C, Pitts K, Letcher S, Tang J, et al.
Immunity
. 2022 Aug;
55(9):1627-1644.e7.
PMID: 35977543
The apolipoprotein E4 (APOE4) allele is associated with an increased risk of Alzheimer disease and a decreased risk of glaucoma, but the underlying mechanisms remain poorly understood. Here, we found...
20.
West P, McCorkindale A, Guennewig B, Ashhurst T, Viengkhou B, Hayashida E, et al.
J Neuroinflammation
. 2022 Apr;
19(1):96.
PMID: 35429976
Background: Elevated production of the cytokines interleukin (IL)-6 or interferon (IFN)-α in the central nervous system (CNS) is implicated in the pathogenesis of neurological diseases such as neuromyelitis optica spectrum...