Ole Paulsen
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Explore the profile of Ole Paulsen including associated specialties, affiliations and a list of published articles.
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103
Citations
4804
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Recent Articles
1.
Brockhoff M, Trauble J, Middya S, Fuchsberger T, Fernandez-Villegas A, Stephens A, et al.
Sci Adv
. 2025 Mar;
11(11):eadr4155.
PMID: 40085717
Microelectrode arrays (MEAs) permit recordings with high electrode counts, thus generating complex datasets that would benefit from precise neuronal spike sorting for meaningful data extraction. Nevertheless, conventional spike sorting methods...
2.
Fuchsberger T, Stockwell I, Woods M, Brzosko Z, Greger I, Paulsen O
Elife
. 2025 Mar;
13.
PMID: 40063079
The reward and novelty-related neuromodulator dopamine plays an important role in hippocampal long-term memory, which is thought to involve protein-synthesis-dependent synaptic plasticity. However, the direct effects of dopamine on protein...
3.
Pasternack N, Paulsen O, Nath A
Front Genet
. 2025 Feb;
16:1498978.
PMID: 39931732
Human endogenous retroviruses (HERV) represent nearly 8% of the human genome. Of these, HERV-K subtype HML-2 is a transposable element that plays a critical role in embryonic development and in...
4.
Sit T, Feord R, Dunn A, Chabros J, Oluigbo D, Smith H, et al.
Cell Rep Methods
. 2024 Nov;
4(11):100901.
PMID: 39520988
Microelectrode array (MEA) recordings are commonly used to compare firing and burst rates in neuronal cultures. MEA recordings can also reveal microscale functional connectivity, topology, and network dynamics-patterns seen in...
5.
Pasternack N, Doucet-OHare T, Johnson K, Paulsen O, Nath A
iScience
. 2024 Jul;
27(7):110147.
PMID: 38989463
Amyotrophic lateral sclerosis (ALS) is a universally fatal neurodegenerative disease with no cure. Human endogenous retroviruses (HERVs) have been implicated in its pathogenesis but their relevance to ALS is not...
6.
Sit T, Feord R, Dunn A, Chabros J, Oluigbo D, Smith H, et al.
bioRxiv
. 2024 Feb;
PMID: 38370637
Microelectrode array (MEA) recordings are commonly used to compare firing and burst rates in neuronal cultures. MEA recordings can also reveal microscale functional connectivity, topology, and network dynamics-patterns seen in...
7.
Fuchsberger T, Clopath C, Jarzebowski P, Brzosko Z, Wang H, Paulsen O
Elife
. 2022 Oct;
11.
PMID: 36226826
A fundamental unresolved problem in neuroscience is how the brain associates in memory events that are separated in time. Here, we propose that reactivation-induced synaptic plasticity can solve this problem....
8.
Fuchsberger T, Paulsen O
Curr Opin Neurobiol
. 2022 Jun;
75:102558.
PMID: 35660989
Synaptic plasticity plays a central role in the study of neural mechanisms of learning and memory. Plasticity rules are not invariant over time but are under neuromodulatory control, enabling behavioral...
9.
Shipton O, Tang C, Paulsen O, Vargas-Caballero M
Acta Neuropathol Commun
. 2022 Apr;
10(1):45.
PMID: 35379353
Amyloid-beta (Aβ) and tau protein are both involved in the pathogenesis of Alzheimer's disease. Aβ produces synaptic deficits in wild-type mice that are not seen in Mapt mice, suggesting that...
10.
Jarzebowski P, Hay Y, Grewe B, Paulsen O
Curr Biol
. 2022 Jan;
32(4):834-841.e5.
PMID: 35016008
Hippocampal place cells fire at specific locations in the environment. They form a cognitive map that encodes spatial relations in the environment, including reward locations. As part of this encoding,...