Oi Kwan Wong
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Explore the profile of Oi Kwan Wong including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
331
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0
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Recent Articles
1.
Chen X, Wong O, Reiman L, Sherbenou D, Post L
Mol Cancer Ther
. 2023 Oct;
23(2):127-138.
PMID: 37816503
The cluster of differentiation 38 (CD38) is a well-validated target for treating multiple myeloma. Although anti-CD38 mAbs have demonstrated outstanding initial responses in patients with multiple myeloma, nearly all patients...
2.
Wong O, Tran T, Ho W, Galindo Casas M, Au M, Bateman M, et al.
Oncotarget
. 2018 Oct;
9(71):33446-33458.
PMID: 30323890
Epidermal growth factor receptor (EGFR) is a clinically validated target and often overexpressed in some solid tumors. Both EGFR tyrosine kinase inhibitors and ligand-blocking antibodies have been approved for treatment...
3.
Strop P, Tran T, Dorywalska M, Delaria K, Dushin R, Wong O, et al.
Mol Cancer Ther
. 2016 Sep;
15(11):2698-2708.
PMID: 27582525
Trop-2, also known as TACSTD2, EGP-1, GA733-1, and M1S1, is frequently expressed on a variety of human carcinomas, and its expression is often associated with poor prognosis of the diseases....
4.
Strop P, Ho W, Boustany L, Abdiche Y, Lindquist K, Farias S, et al.
J Mol Biol
. 2012 May;
420(3):204-19.
PMID: 22543237
Bispecific antibodies and antibody fragments are a new class of therapeutics increasingly utilized in the clinic for T cell recruitment (catumaxomab anti-EpCAM/CD3 and blinatumomab anti-CD19/CD3), increase in the selectivity of...
5.
Hawtin R, Stockett D, Wong O, Lundin C, Helleday T, Fox J
Oncotarget
. 2011 Feb;
1(7):606-619.
PMID: 21317456
Vosaroxin (formerly voreloxin) is a first-in-class anticancer quinolone derivative that intercalates DNA and inhibits topoisomerase II, inducing site-selective double-strand breaks (DSB), G2 arrest and apoptosis. Objective responses and complete remissions...
6.
Wong O, Guthold M, Erie D, Gelles J
PLoS Biol
. 2008 Oct;
6(9):e232.
PMID: 18828671
At many promoters, transcription is regulated by simultaneous binding of a protein to multiple sites on DNA, but the structures and dynamics of such transcription factor-mediated DNA loops are poorly...
7.
Wong O, Fang G
J Cell Biol
. 2007 Nov;
179(4):611-7.
PMID: 17998400
Accurate chromosome segregation is controlled by the spindle checkpoint, which senses kinetochore- microtubule attachments and tension across sister kinetochores. An important step in the tension-signaling pathway involves the phosphorylation of...
8.
Wong O, Fang G
Mol Biol Cell
. 2006 Aug;
17(10):4390-9.
PMID: 16885416
Accurate chromosome segregation is controlled by the spindle checkpoint, which responds to the lack of microtubule-kinetochore attachment or of tension across sister kinetochores through phosphorylation of kinetochore proteins by the...
9.
Wong O, Fang G
J Cell Biol
. 2005 Sep;
170(5):709-19.
PMID: 16129782
Dynamic attachment of microtubules to kinetochores during mitosis generates pulling force, or tension, required for the high fidelity of chromosome separation. A lack of tension activates the spindle checkpoint and...
10.
Gupta A, Inaba S, Wong O, Fang G, Liu J
Oncogene
. 2003 Oct;
22(48):7593-9.
PMID: 14576821
The abnormal expression of breast cancer-specific gene 1 (BCSG1) in malignant mammary epithelial cells is highly associated with the development and progression of breast cancer. A series of in vitro...