Obtin Alkhamis
Overview
Explore the profile of Obtin Alkhamis including associated specialties, affiliations and a list of published articles.
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30
Citations
296
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Recent Articles
1.
Yu H, Canoura J, Byrd C, Alkhamis O, Bacon A, Yan A, et al.
J Am Chem Soc
. 2025 Mar;
PMID: 40053911
The affinity of nucleic acid aptamers isolated via Systematic Evolution of Ligands by Exponential Enrichment (SELEX) is often limited because the entire potential sequence space cannot be screened. In this...
2.
Wang L, Canoura J, Byrd C, Nguyen T, Alkhamis O, Ly P, et al.
ACS Cent Sci
. 2024 Dec;
10(12):2213-2228.
PMID: 39735321
Aptamers are oligonucleotide-based affinity reagents that are increasingly being used in various applications. Systematic evolution of ligands by exponential enrichment (SELEX) has been widely used to isolate aptamers for small-molecule...
3.
Canoura J, Alkhamis O, Byrd C, Wang L, Bryant A, Xiao Y
Anal Chem
. 2024 Oct;
96(44):17720-17729.
PMID: 39454074
selection offers a means of discovering functional nucleic acids from randomized libraries, and high-throughput sequencing (HTS) is a powerful tool for monitoring the evolution of oligonucleotide pools over many cycles...
4.
Wang L, Alkhamis O, Canoura J, Yu H, Xiao Y
J Am Chem Soc
. 2024 Jul;
146(31):21296-21307.
PMID: 39042584
Aptamers are nucleic acid bioreceptors that have been widely utilized for a variety of biosensing applications, including detection methods that would not be possible with antibody-based systems. However, it remains...
5.
Alkhamis O, Canoura J, Wang L, Xiao Y
Sci Adv
. 2024 Jun;
10(24):eadl3426.
PMID: 38865469
Conventional directed evolution methods offer the ability to select bioreceptors with high binding affinity for a specific target in terms of thermodynamic properties. However, there is a lack of analogous...
6.
Canoura J, Alkhamis O, Venzke M, Ly P, Xiao Y
JACS Au
. 2024 Apr;
4(3):1059-1072.
PMID: 38559723
Opioids collectively cause over 80,000 deaths in the United States annually. The ability to rapidly identify these compounds in seized drug samples on-site will be essential for curtailing trafficking and...
7.
Yang K, Alkhamis O, Canoura J, Bryant A, Gong E, Barbu M, et al.
JACS Au
. 2024 Mar;
4(2):760-770.
PMID: 38425914
We reported over 20 years ago MNS-4.1, the first DNA aptamer with a micromolar affinity for cocaine. MNS-4.1 is based on a structural motif that is very common in any...
8.
Alkhamis O, Canoura J, Wu Y, Emmons N, Wang Y, Honeywell K, et al.
J Am Chem Soc
. 2024 Jan;
146(5):3230-3240.
PMID: 38277259
The ability to quantify cocaine in biological fluids is crucial for both the diagnosis of intoxication and overdose in the clinic as well as investigation of the drug's pharmacological and...
9.
Canoura J, Liu Y, Alkhamis O, Xiao Y
Anal Chem
. 2023 Nov;
95(49):18258-18267.
PMID: 38033203
Fentanyl is a widely abused analgesic and anesthetic drug with a narrow therapeutic window that creates easy opportunities for overdose and death. Rapid, accurate, and sensitive fentanyl detection in biosamples...
10.
Alkhamis O, Canoura J, Ly P, Xiao Y
Acc Chem Res
. 2023 Jun;
56(13):1731-1743.
PMID: 37314701
Aptamers are short, single-stranded nucleic acids that have been selected from random libraries to bind specific molecules with high affinity via an method termed systematic evolution of ligands by exponential...