O J T McCarty
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Explore the profile of O J T McCarty including associated specialties, affiliations and a list of published articles.
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20
Citations
708
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Recent Articles
11.
Tormoen G, Rugonyi S, Gruber A, McCarty O
Phys Biol
. 2011 Nov;
8(6):066005.
PMID: 22048420
Tissue factor (TF) is a transmembrane glycoprotein cofactor of activated blood coagulation factor VII (FVIIa) that is required for hemostatic thrombin generation at sites of blood vessel injury. Membrane-associated TF...
12.
Berny-Lang M, Aslan J, Tormoen G, Patel I, Bock P, Gruber A, et al.
Phys Biol
. 2011 Feb;
8(1):015014.
PMID: 21301066
The routine observation of tumor emboli in the peripheral blood of patients with carcinomas raises questions about the clinical relevance of these circulating tumor cells. Thrombosis is a common clinical...
13.
White-Adams T, Berny M, Patel I, Tucker E, Gailani D, Gruber A, et al.
J Thromb Haemost
. 2010 Aug;
8(6):1295-301.
PMID: 20796202
Background: Laminin is the most abundant non-collagenous protein in the basement membrane. Recent studies have shown that laminin supports platelet adhesion, activation and aggregation under flow conditions, highlighting a possible...
14.
Calaminus S, Thomas S, McCarty O, Machesky L, Watson S
J Thromb Haemost
. 2008 Sep;
6(11):1944-52.
PMID: 18761725
Background: During platelet spreading, the actin cytoskeleton undergoes marked changes, forming filopodia, lamellipodia and stress fibres. In the present study, we report the identification of a novel actin-rich structure, termed...
15.
White T, Berny M, Tucker E, Urbanus R, de Groot P, Fernandez J, et al.
J Thromb Haemost
. 2008 May;
6(6):995-1002.
PMID: 18489431
Background: Activated protein C (APC) regulates thrombin generation and inhibits apoptosis. Endothelial protein C receptor (EPCR)-bound protein C is activated by thrombomodulin-bound thrombin. APC inactivates coagulation factors (F)Va/VIIIa and generates...
16.
Calaminus S, Auger J, McCarty O, Wakelam M, Machesky L, Watson S
J Thromb Haemost
. 2007 Jul;
5(10):2136-45.
PMID: 17645784
Background: MyosinIIs are adenosine triphosphate-driven molecular motors that form part of a cell's contractile machinery. They are activated by phosphorylation of their light chains, by either activation of myosin light...
17.
Calaminus S, McCarty O, Auger J, Pearce A, Insall R, Watson S, et al.
J Thromb Haemost
. 2007 Feb;
5(3):535-41.
PMID: 17319906
Background: The small GTPase Rac1 plays a critical role in lamellipodia assembly in platelets on matrix proteins in the absence or presence of G protein-coupled receptor (GPCR) agonists. Rac mediates...
18.
McCarty O, Calaminus S, Berndt M, Machesky L, Watson S
J Thromb Haemost
. 2006 May;
4(6):1367-78.
PMID: 16706984
Background: von Willebrand factor (VWF) plays a critical role in the process of hemostasis by mediating flow-dependent adhesion and spreading of platelets on exposed extracellular matrix proteins following vascular injury....
19.
Watson S, Auger J, McCarty O, Pearce A
J Thromb Haemost
. 2005 Aug;
3(8):1752-62.
PMID: 16102042
This review summarizes recent developments in our understanding of the molecular basis of platelet activation by two distinct types of surface receptor, the immunoglobulin GPVI, and the integrin alphaIIb beta3...
20.
McCarty O, Zhao Y, Andrew N, Machesky L, Staunton D, Frampton J, et al.
J Thromb Haemost
. 2004 Oct;
2(10):1823-33.
PMID: 15456495
Background: Recent studies have shown that platelet adhesion and subsequent aggregation can occur in vivo in the absence of the two principal platelets adhesive ligands, von Willebrand factor and fibrinogen....