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O A Fathalla

Explore the profile of O A Fathalla including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 6
Citations 5
Followers 0
Related Specialties
Pharmacology
Pharmacy
Top 10 Co-Authors
S A Swelam
M E A Zaki
S M Nofal
H S Gad
M S Mohamed
M E Haiba
H F Aly
A S Maghaby
A S Maghraby
S M Awad
Published In
Arch Pharm Res
Acta Pol Pharm
Affiliations
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Recent Articles
1.
Synthesis of new 2-thiouracil-5-sulphonamide derivatives with antibacterial and antifungal activity
Fathalla O, Awad S, Mohamed M
Arch Pharm Res . 2005 Dec; 28(11):1205-12. PMID: 16350842
2-Thiouracil-5-sulphonic acid N-(4-acetylphenyl) Amide (1) was reacted with a series of aromatic aldehydes giving chalcones 2 (Claisen-Schemidt reaction), some of these chalcones were reacted with urea and thiourea giving pyrimidine-2-one...
2.
Synthesis of pyrido[2,1-c][1,2,4]triazine,1,2,4 triazolo[4,3-a] pyridine and 2-(substituted-pyrazolyl)nicotinonitrile and their effect on Biomphalaria alexandrina snail enzymes
Zaki M, Fathalla O, Swelam S, Aly H
Acta Pol Pharm . 2004 Jul; 61(1):55-64. PMID: 15259858
The reaction of 2-hydrazino-4-(4-methoxyphenyl)-6-pheny-nicotinonitrile 3 with halo compounds yielded 4a-c,5,6. Heating 3 with carbon disulphide gave 7-(4-methoxyphenyl)-5-phenyl-3-thioxo-2,3-dihydro [1,2,4-] triazolo [4,3-a] pyridine-8-carboxylic amide 7. The behaviour of 3 towards some alpha,beta-unsaturated...
3.
Facile synthesis of fused pyrazolo[1,5-a]pyrimidinepyrazolo [1,5-a]triazines and N-sulphonamidopyrazoles as antiinflammatory
Fathalla O, Zaki M, Swelam S, Nofal S, El-Eraky W
Acta Pol Pharm . 2003 Jul; 60(1):51-60. PMID: 12848368
Interaction of hydrazine hydrate with methyl (2-E)-2-cyano-3-[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)amino]-3-(methylsulphanyl)-2-propenoate 2 which was obtained by the reaction of methyl-2-cyano-3,3-bis(methylsulphanyl) acrylate 1 with 4-amino-1-phenyl-2,3-dimethyl pyrazoline-5-one afforded methyl-5-amino-3-[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)amino]-1H-pyrazole-4-carboxylate 3a. The pyrazolin derivative 3a is a...
4.
Synthesis of new uracil-5-sulfonamide derivatives and immunostimulatory effect of a chemically modified hemolymph of Biomphalaria alexandrina on Schistosoma mansoni infected mice
Fathalla O, Haiba M, Maghraby A
Arch Pharm Res . 2003 Jun; 26(5):358-66. PMID: 12785731
Some N-p-substituted phenyl uracil-5-sulphonamide derivatives have been synthesized to be evaluated as molluscicides against Biomphalanaria alexandrina snails, the intermediate host of Schistosoma mansoni. Schistosoma mansoni infected mice were treated with...
5.
Synthesis of new uracil-5-sulphonamide-p-phenyl derivatives and their effect on Biomphalaria alexandrina snail's nucleoproteins
Fathalla O, Gad H, Maghaby A
Arch Pharm Res . 2000 Jun; 23(2):128-38. PMID: 10836738
In continuation of the previous work (Fathalla, 1992) on the synthesis of some heterocycles containing uracil moiety, we report herein the incorporation of uracil moiety into cyanopyridine thione, thiosemecarbazone, semicarbazone,...
6.
Synthesis of new pyrazolo[1,5-a]pyrimidine derivative using 5-aminouracil and ketene dithioacetal
Fathalla O
Arch Pharm Res . 2000 Jan; 22(6):571-4. PMID: 10615862
Novel 3-cyano-2-(3-uracilyl-5-amino) pyrazolo [1,5-a]pyrimidine has been synthesized using 5-aminouracil as a starting material.