Nuno M Xavier
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Explore the profile of Nuno M Xavier including associated specialties, affiliations and a list of published articles.
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18
Citations
36
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Recent Articles
1.
Ali-Rachedi F, Cowling S, Xavier N, Goodby J, Yue X, Chambert S, et al.
Chemistry
. 2025 Jan;
31(11):e202403678.
PMID: 39821943
In this article we describe research on the synthesis and characterization of a family of "Janus" amphiphiles composed of disaccharide head groups and alkaloid units joined together via a methylene...
2.
Moreau F, Atamanyuk D, Blaukopf M, Barath M, Herczeg M, Xavier N, et al.
J Med Chem
. 2024 Apr;
67(8):6610-6623.
PMID: 38598312
Inhibition of the biosynthesis of bacterial heptoses opens novel perspectives for antimicrobial therapies. The enzyme GmhA responsible for the first committed biosynthetic step catalyzes the conversion of sedoheptulose 7-phosphate into...
3.
Xavier N, Andreana P
Pharmaceuticals (Basel)
. 2024 Mar;
17(3).
PMID: 38543110
This Special Issue of presents one review and six original articles that are demonstrative of the importance of glycomimetics and glycoconjugates as privileged groups of carbohydrate-based molecules in the search...
4.
Moreira T, Manuel D, Rosa J, Nunes R, Vojackova V, Jorda R, et al.
ChemMedChem
. 2023 Dec;
19(3):e202300608.
PMID: 38095428
The synthesis and antiproliferative evaluation of novel d-glucopyranuronamide-containing nucleosides is described. Based on our previously reported anticancer d-glucuronamide-based nucleosides, new analogues comprising N/O-dodecyl or N-propargyl substituents at the glucuronamide unit...
5.
Fortuna A, Goncalves-Pereira R, Costa P, Jorda R, Vojackova V, Gonzalez G, et al.
ChemMedChem
. 2022 May;
17(14):e202200180.
PMID: 35576106
The synthesis and biological evaluation of novel guanidino sugars as isonucleoside analogs is described. 5-Guanidino xylofuranoses containing 3-O-saturated/unsaturated hydrocarbon or aromatic-containing moieties were accessed from 5-azido xylofuranoses via reduction followed...
6.
Xavier N, Andreana P, Carvalho I, von Itzstein M
Front Chem
. 2021 Mar;
9:655200.
PMID: 33748078
No abstract available.
7.
Fortuna A, Costa P, Piedade M, Oliveira M, Xavier N
Chempluschem
. 2020 Aug;
85(8):1676-1691.
PMID: 32757384
The synthesis of stable and potentially bioactive xylofuranosyl nucleoside analogues and potential sugar diphosphate or nucleotide mimetics comprising a 1,2,3-triazole moiety is reported. 3'-O-Methyl-branched N-benzyltriazole isonucleosides were accessed in 5-7...
8.
Xavier N, de Sousa E, Pereira M, Loesche A, Serbian I, Csuk R, et al.
Pharmaceuticals (Basel)
. 2019 Jul;
12(3).
PMID: 31269639
Isonucleosides are rather stable regioisomeric analogs of nucleosides with broad therapeutic potential. We have previously demonstrated the ability of 5' and 6'-isonucleosides to inhibit the activity of acetylcholinesterase, a major...
9.
Dias C, Pais J, Nunes R, Blazquez-Sanchez M, Marques J, Almeida A, et al.
Nat Commun
. 2018 Nov;
9(1):4857.
PMID: 30451842
Anthrax is an infectious disease caused by Bacillus anthracis, a bioterrorism agent that develops resistance to clinically used antibiotics. Therefore, alternative mechanisms of action remain a challenge. Herein, we disclose...
10.
Xavier N, Porcheron A, Batista D, Jorda R, Reznickova E, Krystof V, et al.
Org Biomol Chem
. 2017 May;
15(21):4667-4680.
PMID: 28517004
The synthesis and anticancer evaluation of novel N-glycosyl derivatives containing N-substituted glucuronamide moieties, as nucleoside analogs or as prospective mimetics of glycosyl phosphates or of nucleotides, is reported. These compounds...