Nuno F da Costa
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Explore the profile of Nuno F da Costa including associated specialties, affiliations and a list of published articles.
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7
Citations
14
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Recent Articles
1.
da Costa N, Azevedo R, Lopes J, Fernandes A, Pinto J
Pharmaceutics
. 2022 Dec;
14(12).
PMID: 36559080
In situ amorphization is a promising approach, considered in the present work, to enhance the solubility and dissolution rate of olanzapine, while minimizing the exposure of the amorphous material to...
2.
da Costa N, Daniels R, Fernandes A, Pinto J
Int J Mol Sci
. 2022 Sep;
23(18).
PMID: 36142179
The preparation of amorphous and co-amorphous systems (CAMs) effectively addresses the solubility and bioavailability issues of poorly water-soluble chemical entities. However, stress conditions imposed during common pharmaceutical processing (e.g., tableting)...
3.
da Costa N, Santos I, Fernandes A, Pinto J
J Pharm Sci
. 2022 Aug;
111(12):3327-3339.
PMID: 36007560
Co-amorphization is a promising approach to stabilize drugs in the amorphous form. Olanzapine, a poorly water-soluble drug was used in this study. Sulfonic acids (saccharin, cyclamic acid and acesulfame), free...
4.
da Costa N, Daniels R, Fernandes A, Pinto J
Pharmaceutics
. 2022 Jul;
14(8).
PMID: 35893791
The work evaluates the stability of amorphous and co-amorphous olanzapine (OLZ) in tablets manufactured by direct compression. The flowability and the compressibility of amorphous and co-amorphous OLZ with saccharin (SAC)...
5.
Macedo J, da Costa N, Vanhoorne V, Vervaet C, Pinto J
J Pharm Sci
. 2022 May;
111(10):2814-2826.
PMID: 35577114
Tablet manufacture by fused deposition modelling (FDM) can be carried out individually (one tablet printed per run) or as a group (i.e., 'multiple printing' in one run) depending on patient's...
6.
da Costa N, Fernandes A, Pinto J
Int J Pharm
. 2020 Aug;
588:119716.
PMID: 32758593
Amorphous and co-amorphous formulations have been used to enhance the solubility and bioavailability of poorly water-soluble drugs. However, during handling and/or storage amorphous solids present inherent instability and overtime recrystallize...
7.
Pombo S, da Costa N, Figueira M
Braz J Psychiatry
. 2014 Nov;
37(1):40-8.
PMID: 25372059
Objective: To evaluate the dichotomy of type I/II and type A/B alcoholism typologies in opiate-dependent patients with a comorbid alcohol dependence problem (ODP-AP). Methods: The validity assessment process comprised the...