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Norbert Goebels

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Articles 45
Citations 1381
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Recent Articles
1.
Rauber S, Schulte-Mecklenbeck A, Willison A, Hagler R, Jonas M, Pul D, et al.
J Neuroinflammation . 2024 Nov; 21(1):286. PMID: 39497174
Background: Immune dysregulation is a hallmark of autoimmune diseases of the central nervous system (CNS), characterized by an excessive immune response, and primary CNS tumors (pCNS-tumors) showing a highly immunosuppressive...
2.
Caduff N, Rieble L, Boni M, McHugh D, Roshan R, Miley W, et al.
Nat Commun . 2024 Jun; 15(1):4841. PMID: 38844783
Kaposi sarcoma associated herpesvirus (KSHV) is associated with around 1% of all human tumors, including the B cell malignancy primary effusion lymphoma (PEL), in which co-infection with the Epstein Barr...
3.
Sabet M, Barman S, Beller M, Meuth S, Melzer N, Aktas O, et al.
Int J Mol Sci . 2023 Jan; 24(1). PMID: 36613687
Anti-NMDA receptor (NMDAR) encephalitis is frequently associated with demyelinating disorders (e.g., multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), myelin oligodendrocyte glycoprotein-associated disease (MOGAD)) with regard to clinical presentation, neuropathological...
4.
Ruck T, Barman S, Schulte-Mecklenbeck A, Pfeuffer S, Steffen F, Nelke C, et al.
Brain . 2022 Jun; 145(5):1711-1725. PMID: 35661859
Alemtuzumab is a monoclonal antibody that causes rapid depletion of CD52-expressing immune cells. It has proven to be highly efficacious in active relapsing-remitting multiple sclerosis; however, the high risk of...
5.
Strippel C, Herrera-Rivero M, Wendorff M, Tietz A, Degenhardt F, Witten A, et al.
Brain . 2022 Mar; 146(3):977-990. PMID: 35348614
Autoimmune neurological syndromes (AINS) with autoantibodies against the 65 kDa isoform of the glutamic acid decarboxylase (GAD65) present with limbic encephalitis, including temporal lobe seizures or epilepsy, cerebellitis with ataxia,...
6.
Wright S, Rosch R, Wilson M, Upadhya M, Dhangar D, Clarke-Bland C, et al.
Commun Biol . 2021 Sep; 4(1):1106. PMID: 34545200
Seizures are a prominent feature in N-Methyl-D-Aspartate receptor antibody (NMDAR antibody) encephalitis, a distinct neuro-immunological disorder in which specific human autoantibodies bind and crosslink the surface of NMDAR proteins thereby...
7.
Wiendl H, Gold R, Berger T, Derfuss T, Linker R, Maurer M, et al.
Ther Adv Neurol Disord . 2021 Aug; 14:17562864211039648. PMID: 34422112
Multiple sclerosis is a complex, autoimmune-mediated disease of the central nervous system characterized by inflammatory demyelination and axonal/neuronal damage. The approval of various disease-modifying therapies and our increased understanding of...
8.
Wiendl H, Gold R, Berger T, Derfuss T, Linker R, Maurer M, et al.
Nervenarzt . 2021 Jul; 92(8):773-801. PMID: 34297142
Multiple sclerosis is a complex, autoimmune-mediated disease of the central nervous system characterized by inflammatory demyelination and axonal/neuronal damage. The approval of various disease-modifying therapies and our increased understanding of...
9.
Baetge S, Dietrich M, Filser M, Renner A, Stute N, Gasis M, et al.
Neurol Neuroimmunol Neuroinflamm . 2021 May; 8(4). PMID: 34045307
Objective: Retinal layer thickness (RLT) measured by optical coherence tomography (OCT) is considered a noninvasive, cost-efficient marker of neurodegeneration in multiple sclerosis (MS). We aimed to investigate associations of RLT...
10.
Baksmeier C, Blundell P, Steckel J, Schultz V, Gu Q, da Silva Filipe A, et al.
Immunology . 2021 Apr; 164(1):90-105. PMID: 33880776
Intravenous immunoglobulin (IVIG) is an established treatment for numerous autoimmune conditions. Although Fc fragments derived from IVIG have shown efficacy in controlling immune thrombocytopenia in children, the mechanisms of action...