Nobuyuki Akita
Overview
Explore the profile of Nobuyuki Akita including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
181
Followers
0
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Recent Articles
1.
Hiramoto K, Akita N, Nishioka J, Suzuki K
TH Open
. 2023 Feb;
7(1):e1-e13.
PMID: 36751299
Certain low-molecular-weight heparins have been reported to reduce tumor growth and metastasis in tumor cell-inoculated mouse models and cancer patients. Recently, direct oral anticoagulants (DOACs) have been widely used in...
2.
Okada M, Tominaga N, Honda G, Nishioka J, Akita N, Hayashi T, et al.
Blood Adv
. 2020 Jun;
4(12):2631-2639.
PMID: 32556284
Thrombomodulin functions as an anticoagulant through thrombin binding and protein C activation. We herein report the first case of hereditary functional thrombomodulin deficiency presenting with recurrent subcutaneous hemorrhage and old...
3.
Okamoto T, Akita N, Terasawa M, Hayashi T, Suzuki K
J Nat Med
. 2019 Feb;
73(3):614-619.
PMID: 30796650
Rhamnan sulfate (RS) is a polysaccharide with a rhamnose backbone isolated from Monostroma nitidum. Like heparin, it exerts anticoagulant activity in the presence of antithrombin. Endothelial cells facilitate the crosstalk...
4.
Yoshida K, Akita N, Okamoto T, Asanuma K, Uchida A, Sudo A, et al.
Thromb Res
. 2018 Jan;
163:30-40.
PMID: 29334656
Introduction: Bone remodeling relies on a delicate balance between formation and resorption of bone tissues, processes in which bone-forming osteoblasts and bone-resorbing osteoclasts play central roles. Recently, we reported that...
5.
Okamoto T, Kawamoto E, Takagi Y, Akita N, Hayashi T, Park E, et al.
Sci Rep
. 2017 Jul;
7(1):6134.
PMID: 28733642
Endothelial monolayers have shown the ability to signal each other through gap junctions. Gap junction-mediated cell-cell interactions have been implicated in the modulation of endothelial cell functions during vascular inflammation....
6.
Akita N, Ma N, Okamoto T, Asanuma K, Yoshida K, Nishioka J, et al.
Thromb Res
. 2015 Apr;
135(6):1203-8.
PMID: 25887633
Introduction: Protein C inhibitor (PCI), a member of the serine protease inhibitor family, is expressed in various human tissues, including liver and kidneys. In the plasma, PCI physiologically inhibits an...
7.
Okamoto T, Akita N, Hayashi T, Shimaoka M, Suzuki K
Atherosclerosis
. 2014 Aug;
236(2):430-7.
PMID: 25171777
Objective: Endothelial cell (EC) interacts with adjacent EC through gap junction, and abnormal expression or function of Cxs is associated with cardiovascular diseases. In patients with endothelial dysfunction, the up-regulation...
8.
Okamoto T, Akita N, Kawamoto E, Hayashi T, Suzuki K, Shimaoka M
Exp Cell Res
. 2013 Dec;
321(2):133-41.
PMID: 24333598
The gap junction proteins connexin32 (Cx32), Cx37, Cx40, and Cx43 are expressed in endothelial cells, and regulate vascular functions involving inflammation, vasculogenesis and vascular remodeling. Aberrant Cxs expression promotes the...
9.
Okamoto T, Akita N, Nagai M, Hayashi T, Suzuki K
J Nat Med
. 2013 Jun;
68(1):144-53.
PMID: 23760613
6-Methylsulfinylhexyl isothiocyanate (6-MSITC) is an active compound in wasabi (Wasabia japonica Matsum.), which is one of the most popular spices in Japan. 6-MSITC suppresses lipopolysaccharide-induced macrophage activation, arachidonic- or adenosine...
10.
Rao T, Okamoto T, Akita N, Hayashi T, Kato-Yasuda N, Suzuki K
Br J Nutr
. 2013 Jun;
110(12):2201-6.
PMID: 23742702
Amla (Emblica officinalis Gaertn.) has been used for many centuries in traditional Indian Ayurvedic formulations for the prevention and treatment of many inflammatory diseases. The present study evaluated the anti-inflammatory...