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Niraja N Ranadive

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Hesketh L, Wilder C, Ranadive N, Lytra G, Qazimi P, Munro J, et al.
Sci Rep . 2020 May; 10(1):8397. PMID: 32439959
The 'translational therapeutic index' (TTI) is a drug's ratio of nonclinical threshold dose (or concentration) for significant benefit versus threshold for adversity. In early nonclinical research, discovery and safety studies...