Nina Heycke
Overview
Explore the profile of Nina Heycke including associated specialties, affiliations and a list of published articles.
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7
Citations
437
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Recent Articles
1.
Brands J, Bravo S, Jurgenliemke L, Gratz L, Schihada H, Frechen F, et al.
Nat Commun
. 2024 Sep;
15(1):7684.
PMID: 39227390
A long-held tenet in inositol-lipid signaling is that cleavage of membrane phosphoinositides by phospholipase Cβ (PLCβ) isozymes to increase cytosolic Ca in living cells is exclusive to Gq- and Gi-sensitive...
2.
Patt J, Alenfelder J, Pfeil E, Voss J, Merten N, Eryilmaz F, et al.
J Biol Chem
. 2021 Feb;
296:100472.
PMID: 33639168
Heterotrimeric G protein subunits Gαq and Gα11 are inhibited by two cyclic depsipeptides, FR900359 (FR) and YM-254890 (YM), both of which are being used widely to implicate Gq/11 proteins in...
3.
Pfeil E, Brands J, Merten N, Vogtle T, Vescovo M, Rick U, et al.
Mol Cell
. 2020 Nov;
80(6):940-954.e6.
PMID: 33202251
Mechanisms that control mobilization of cytosolic calcium [Ca] are key for regulation of numerous eukaryotic cell functions. One such paradigmatic mechanism involves activation of phospholipase Cβ (PLCβ) enzymes by G...
4.
Annala S, Feng X, Shridhar N, Eryilmaz F, Patt J, Yang J, et al.
Sci Signal
. 2019 Mar;
12(573).
PMID: 30890659
Somatic gain-of-function mutations of and , which encode α subunits of heterotrimeric Gα proteins, occur in about 85% of cases of uveal melanoma (UM), the most common cancer of the...
5.
Reher R, Kuschak M, Heycke N, Annala S, Kehraus S, Dai H, et al.
J Nat Prod
. 2018 Jun;
81(7):1628-1635.
PMID: 29943987
The cyclic depsipeptide FR900359 (FR), isolated from the traditional Chinese medicine plant Ardisia crenata, is a potent Gq protein inhibitor and thus a valuable tool to study Gq-mediated signaling of...
6.
Wilson M, Mori T, Ruckert C, Uria A, Helf M, Takada K, et al.
Nature
. 2014 Jan;
506(7486):58-62.
PMID: 24476823
Cultivated bacteria such as actinomycetes are a highly useful source of biomedically important natural products. However, such 'talented' producers represent only a minute fraction of the entire, mostly uncultivated, prokaryotic...
7.
Fisch K, Gurgui C, Heycke N, van der Sar S, A Anderson S, Webb V, et al.
Nat Chem Biol
. 2009 May;
5(7):494-501.
PMID: 19448639
There is increasing evidence that uncultivated bacterial symbionts are the true producers of numerous bioactive compounds isolated from marine sponges. The localization and heterologous expression of biosynthetic genes could clarify...