Nimit L Patel
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Explore the profile of Nimit L Patel including associated specialties, affiliations and a list of published articles.
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23
Citations
510
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Recent Articles
1.
Shrestha P, Patel N, Kalen J, Usama S, Schnermann M
J Am Chem Soc
. 2025 Mar;
147(10):8280-8288.
PMID: 40025700
Monoclonal antibodies (mAbs) are essential agents for cancer treatment and diagnosis. Advanced optical imaging strategies have the potential to address specific questions regarding their complex in vivo life cycle. This...
2.
Li X, Patel N, Kalen J, Schnermann M
Angew Chem Int Ed Engl
. 2024 Dec;
64(6):e202417651.
PMID: 39696914
Targeted payload delivery strategies, such as antibody-drug conjugates (ADCs), have emerged as important therapeutics. Although considerable efforts have been made in the areas of antibody engineering and labeling methodology, improving...
3.
Krishnamurthy M, Dhall A, Sahoo S, Schultz C, Baird M, Desai P, et al.
bioRxiv
. 2024 Oct;
PMID: 39416100
Metastasis is the leading cause of cancer-related deaths, yet its regulatory mechanisms are not fully understood. Small-cell lung cancer (SCLC) is the most metastatic form of lung cancer, with most...
4.
Torres Chavez A, McKenna M, Balasubramanian K, Riffle L, Patel N, Kalen J, et al.
Mol Ther Oncol
. 2024 Apr;
32(1):200763.
PMID: 38596291
Bioluminescence imaging is a well-established platform for evaluating engineered cell therapies in preclinical studies. However, despite the discovery of new luciferases and substrates, optimal combinations to simultaneously monitor two cell...
5.
Feng Y, Lee J, Yang L, Hilton M, Morris K, Seaman S, et al.
Cell Rep
. 2023 Nov;
42(12):113503.
PMID: 38019654
CD276/B7-H3 represents a promising target for cancer therapy based on widespread overexpression in both cancer cells and tumor-associated stroma. In previous preclinical studies, CD276 antibody-drug conjugates (ADCs) exploiting a talirine-type...
6.
Usama S, Marker S, Li D, Caldwell D, Stroet M, Patel N, et al.
J Am Chem Soc
. 2023 Jun;
145(27):14647-14659.
PMID: 37367935
Heptamethine indocyanines are invaluable probes for near-infrared (NIR) imaging. Despite broad use, there are only a few synthetic methods to assemble these molecules, and each has significant limitations. Here, we...
7.
Sanders C, Matthews R, Esfahani S, Khan N, Patel N, Kalen J, et al.
Vaccine
. 2023 Jun;
41(31):4480-4487.
PMID: 37270364
The species and tissue specificities of HPV (human papillomavirus) for human infection and disease complicates the process of prophylactic vaccine development in animal models. HPV pseudoviruses (PsV) that carry only...
8.
Li D, Gamage R, Oliver A, Patel N, Usama S, Kalen J, et al.
Angew Chem Int Ed Engl
. 2023 May;
62(28):e202305062.
PMID: 37163228
Heptamethine cyanine dyes enable deep tissue fluorescence imaging in the near infrared (NIR) window. Small molecule conjugates of the benchmark dye ZW800-1 have been tested in humans. However, long-term imaging...
9.
Usama S, Caldwell D, Shrestha P, Luciano M, Patel N, Kalen J, et al.
Biosens Bioelectron
. 2022 Sep;
217:114610.
PMID: 36137483
Activatable fluorophores with emission beyond 1000 nm have the potential to enable high contrast imaging in complex in vivo settings. However, there are few scaffolds that can be applied to...
10.
Sahu S, Albaugh M, Martin B, Patel N, Riffle L, Mackem S, et al.
Sci Rep
. 2022 May;
12(1):7200.
PMID: 35504930
Signaling pathways play an important role in cell fate determination in stem cells and regulate a plethora of developmental programs, the dysregulation of which can lead to human diseases. Growth...