Nilesh Samani
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Explore the profile of Nilesh Samani including associated specialties, affiliations and a list of published articles.
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28
Citations
3880
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Recent Articles
11.
Keenan T, Zhao W, Rasheed A, Ho W, Malik R, Felix J, et al.
J Am Coll Cardiol
. 2016 Jan;
67(4):407-416.
PMID: 26821629
Background: Although epidemiological studies have reported positive associations between circulating urate levels and cardiometabolic diseases, causality remains uncertain. Objectives: Through a Mendelian randomization approach, we assessed whether serum urate levels...
12.
Willer C, Schmidt E, Sengupta S, Peloso G, Gustafsson S, Kanoni S, et al.
Nat Genet
. 2013 Oct;
45(11):1274-1283.
PMID: 24097068
Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known...
13.
Do R, Willer C, Schmidt E, Sengupta S, Gao C, Peloso G, et al.
Nat Genet
. 2013 Oct;
45(11):1345-52.
PMID: 24097064
Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this...
14.
Alvarez-Madrazo S, MacKenzie S, Davies E, Fraser R, Lee W, Brown M, et al.
Hypertension
. 2012 Nov;
61(1):232-9.
PMID: 23150505
The locus encompassing the corticosteroidogenic genes CYP11B2 and CYP11B1 is of potential importance in essential hypertension. We analyzed the association of polymorphisms at this locus with risk of essential hypertension,...
15.
Angelakopoulou A, Shah T, Sofat R, Shah S, Berry D, Cooper J, et al.
Eur Heart J
. 2011 Aug;
33(3):393-407.
PMID: 21804106
Aims: To evaluate the associations of emergent genome-wide-association study-derived coronary heart disease (CHD)-associated single nucleotide polymorphisms (SNPs) with established and emerging risk factors, and the association of genome-wide-association study-derived lipid-associated...
16.
Evans D, Spencer C, Pointon J, Su Z, Harvey D, Kochan G, et al.
Nat Genet
. 2011 Jul;
43(8):761-7.
PMID: 21743469
Ankylosing spondylitis is a common form of inflammatory arthritis predominantly affecting the spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent. Here we report...
17.
Lee J, Lees C, Prescott N, Anderson C, Phillips A, Wesley E, et al.
Nat Genet
. 2009 Nov;
41(12):1330-4.
PMID: 19915572
Ulcerative colitis is a common form of inflammatory bowel disease with a complex etiology. As part of the Wellcome Trust Case Control Consortium 2, we performed a genome-wide association scan...
18.
Sober S, Org E, Kepp K, Juhanson P, Eyheramendy S, Gieger C, et al.
PLoS One
. 2009 Jun;
4(6):e6034.
PMID: 19562039
The outcome of Genome-Wide Association Studies (GWAS) has challenged the field of blood pressure (BP) genetics as previous candidate genes have not been among the top loci in these scans....
19.
Org E, Eyheramendy S, Juhanson P, Gieger C, Lichtner P, Klopp N, et al.
Hum Mol Genet
. 2009 Mar;
18(12):2288-96.
PMID: 19304780
Hypertension is a complex disease that affects a large proportion of adult population. Although approximately half of the inter-individual variance in blood pressure (BP) level is heritable, identification of genes...
20.
Kelly D, Khan S, Thompson M, Cockerill G, Ng L, Samani N, et al.
Eur Heart J
. 2008 Jul;
29(17):2116-24.
PMID: 18614523
Aims: Matrix metalloproteinase (MMP) activity is central to the development of left ventricular (LV) remodelling and dysfunction after acute myocardial infarction (AMI). We assessed the relationships with LV structure and...