Nikolas Layer
Overview
Explore the profile of Nikolas Layer including associated specialties, affiliations and a list of published articles.
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8
Citations
70
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Recent Articles
1.
Tetzlaff S, Reyhan E, Layer N, Bengtson C, Heuer A, Schroers J, et al.
Cell
. 2024 Dec;
188(2):390-411.e36.
PMID: 39644898
Glioblastomas are invasive brain tumors with high therapeutic resistance. Neuron-to-glioma synapses have been shown to promote glioblastoma progression. However, a characterization of tumor-connected neurons has been hampered by a lack...
2.
Layer N, Bunse L, Venkataramani V
Cancer Cell
. 2024 May;
42(6):936-938.
PMID: 38821062
Cellular mechanisms mediating immunotherapy resistances are incompletely understood. In this issue, Li et al. reveal how breast cancer hijacks neuronal mechanisms of neuroprotection to shield itself from the immune system....
3.
Layer N, Sonnenberg L, Gonzalez E, Benda J, Hedrich U, Lerche H, et al.
Front Cell Neurosci
. 2021 Nov;
15:754530.
PMID: 34776868
Dravet syndrome (DS) is a developmental epileptic encephalopathy mainly caused by functional Na1.1 haploinsufficiency in inhibitory interneurons. Recently, a new conditional mouse model expressing the recurrent human p.(Ala1783Val) missense variant...
4.
Layer N, Brandes J, Luhrs P, Wuttke T, Koch H
Epilepsia
. 2021 Sep;
62(11):2790-2803.
PMID: 34553376
Objective: Lamotrigine and other sodium-channel blocking agents are among the most commonly used antiepileptic drugs (AEDs). Because other sodium channel blockers, such as riluzole, can severely alter respiratory rhythm generation...
5.
Wickham J, Corna A, Schwarz N, Uysal B, Layer N, Honegger J, et al.
Front Neurosci
. 2020 May;
14:283.
PMID: 32372899
Human cerebrospinal fluid (hCSF) has proven advantageous over conventional medium for culturing both rodent and human brain tissue. In addition, increased activity and synchrony, closer to the dynamic states exclusively...
6.
Schwarz N, Uysal B, Welzer M, Bahr J, Layer N, Loffler H, et al.
Elife
. 2019 Sep;
8.
PMID: 31498083
Most of our knowledge on human CNS circuitry and related disorders originates from model organisms. How well such data translate to the human CNS remains largely to be determined. Human...
7.
Melkonyan M, Hunanyan L, Lourhmati A, Layer N, Beer-Hammer S, Yenkoyan K, et al.
Int J Mol Sci
. 2017 Dec;
19(1).
PMID: 29267189
Locus coeruleus-noradrenergic system dysfunction is known to contribute to the progression of Alzheimer's disease (AD). Besides a variety of reports showing the involvement of norepinephrine and its receptor systems in...
8.
Oquendo M, Layer N, Wagner R, Krippeit-Drews P, Drews G
Pflugers Arch
. 2017 Dec;
470(3):537-547.
PMID: 29218453
We have shown previously that genetic or pharmacological deletion of K channels protect against beta cell dysfunction induced by reactive oxygen species (ROS). Since it is assumed that glucolipotoxicity (GLTx)...