Nikolaos M Tsoukias
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Explore the profile of Nikolaos M Tsoukias including associated specialties, affiliations and a list of published articles.
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32
Citations
640
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Recent Articles
1.
Mughal A, Hennig G, Heppner T, Tsoukias N, Hill-Eubanks D, Nelson M
Proc Natl Acad Sci U S A
. 2024 Dec;
121(51):e2415047121.
PMID: 39661063
The routing of blood flow throughout the brain vasculature is precisely controlled by mechanisms that serve to maintain a fine balance between local neuronal demands and vascular supply of nutrients....
2.
Gonzales A, Klug N, Moshkforoush A, Lee J, Lee F, Shui B, et al.
Proc Natl Acad Sci U S A
. 2020 Oct;
117(43):27022-27033.
PMID: 33051294
The essential function of the circulatory system is to continuously and efficiently supply the O and nutrients necessary to meet the metabolic demands of every cell in the body, a...
3.
Moshkforoush A, Ashenagar B, Harraz O, Dabertrand F, Longden T, Nelson M, et al.
Proc Natl Acad Sci U S A
. 2020 Jul;
117(28):16626-16637.
PMID: 32601236
Neuronal activity leads to an increase in local cerebral blood flow (CBF) to allow adequate supply of oxygen and nutrients to active neurons, a process termed neurovascular coupling (NVC). We...
4.
Moshkforoush A, Ashenagar B, Tsoukias N, Alevriadou B
Sci Rep
. 2019 Nov;
9(1):17072.
PMID: 31745211
Upon inositol trisphosphate (IP) stimulation of non-excitable cells, including vascular endothelial cells, calcium (Ca) shuttling between the endoplasmic reticulum (ER) and mitochondria, facilitated by complexes called Mitochondria-Associated ER Membranes (MAMs),...
5.
Koide M, Moshkforoush A, Tsoukias N, Hill-Eubanks D, Wellman G, Nelson M, et al.
Microcirculation
. 2017 Dec;
25(1).
PMID: 29247493
Cerebral SVDs encompass a group of genetic and sporadic pathological processes leading to brain lesions, cognitive decline, and stroke. There is no specific treatment for SVDs, which progress silently for...
6.
Kapela A, Behringer E, Segal S, Tsoukias N
Microcirculation
. 2017 Nov;
25(2).
PMID: 29117630
Objective: Electrical signaling along the endothelium underlies spreading vasodilation and blood flow control. We use mathematical modeling to determine the electrical properties of the endothelium and gain insight into the...
7.
Parikh J, Kapela A, Tsoukias N
Am J Physiol Heart Circ Physiol
. 2017 Jan;
312(4):H854-H866.
PMID: 28130333
We used mathematical modeling to investigate nitric oxide (NO)-dependent vasodilatory signaling in the arteriolar wall. Detailed continuum cellular models of calcium (Ca) dynamics and membrane electrophysiology in smooth muscle and...
8.
Ho I, Moshkforoush A, Hong K, Meininger G, Hill M, Tsoukias N, et al.
Phys Rev E
. 2016 May;
93:042415.
PMID: 27176337
On the basis of experimental data and mathematical equations in the literature, we remodel the ionic dynamics of smooth muscle cells (SMCs) as an eigensystem formulation, which is valid for...
9.
Scheitlin C, Julian J, Shanmughapriya S, Madesh M, Tsoukias N, Alevriadou B
Am J Physiol Cell Physiol
. 2016 Jan;
310(6):C479-90.
PMID: 26739489
Shear stress is known to stimulate an intracellular free calcium concentration ([Ca(2+)]i) response in vascular endothelial cells (ECs). [Ca(2+)]i is a key second messenger for signaling that leads to vasodilation...
10.
Stochastic model of endothelial TRPV4 calcium sparklets: effect of bursting and cooperativity on EDH
Parikh J, Kapela A, Tsoukias N
Biophys J
. 2015 Mar;
108(6):1566-1576.
PMID: 25809269
We examined the endothelial transient receptor vanilloid 4 (TRPV4) channel's vasodilatory signaling using mathematical modeling. The model analyzes experimental data by Sonkusare and coworkers on TRPV4-induced endothelial Ca(2+) events (sparklets)....