Nikolai Klena
Overview
Explore the profile of Nikolai Klena including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
396
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0
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Recent Articles
1.
Muller A, Klena N, Pang S, Garcia L, Topcheva O, Aurrecoechea Duran S, et al.
Nat Commun
. 2024 Oct;
15(1):9168.
PMID: 39448638
Primary cilia are sensory organelles present in many cell types, partaking in various signaling processes. Primary cilia of pancreatic beta cells play pivotal roles in paracrine signaling and their dysfunction...
2.
Nguyen H, Perone G, Klena N, Vazzana R, Kaluthantrige Don F, Silva M, et al.
Nat Methods
. 2024 Sep;
21(9):1693-1701.
PMID: 39271806
Cryo-focused ion beam milling has substantially advanced our understanding of molecular processes by opening windows into cells. However, applying this technique to complex samples, such as tissues, has presented considerable...
3.
Alvarez Viar G, Klena N, Martino F, Nievergelt A, Bolognini D, Capasso P, et al.
Curr Biol
. 2024 Sep;
34(19):4464-4475.e9.
PMID: 39270640
Controlling ciliary beating is essential for motility and signaling in eukaryotes. This process relies on the regulation of various axonemal proteins that assemble in stereotyped patterns onto individual microtubules of...
4.
Muronova J, Kherraf Z, Giordani E, Lambert E, Eckert S, Cazin C, et al.
Elife
. 2024 Mar;
12.
PMID: 38441556
From a cohort of 167 infertile patients suffering from multiple morphological abnormalities of the flagellum (MMAF), pathogenic bi-allelic mutations were identified in the gene. In somatic cells, CCDC146 is located...
5.
Klena N, Maltinti G, Batman U, Pigino G, Guichard P, Hamel V
Bio Protoc
. 2023 Sep;
13(17):e4792.
PMID: 37719077
Expansion microscopy is an innovative method that enables super-resolution imaging of biological materials using a simple confocal microscope. The principle of this method relies on the physical isotropic expansion of...
6.
van den Hoek H, Klena N, Jordan M, Alvarez Viar G, Righetto R, Schaffer M, et al.
Science
. 2022 Jul;
377(6605):543-548.
PMID: 35901159
The cilium is an antenna-like organelle that performs numerous cellular functions, including motility, sensing, and signaling. The base of the cilium contains a selective barrier that regulates the entry of...
7.
Klena N, Pigino G
Annu Rev Cell Dev Biol
. 2022 Jun;
38:103-123.
PMID: 35767872
Cilia are ubiquitous microtubule-based eukaryotic organelles that project from the cell to generate motility or function in cellular signaling. Motile cilia or flagella contain axonemal dynein motors and other complexes...
8.
Laporte M, Klena N, Hamel V, Guichard P
Nat Methods
. 2022 Jan;
19(2):216-222.
PMID: 35027766
Cryofixation has proven to be the gold standard for efficient preservation of native cell ultrastructure compared to chemical fixation, but this approach is not widely used in fluorescence microscopy owing...
9.
Angerani S, Lindberg E, Klena N, Bleck C, Aumeier C, Winssinger N
Nat Commun
. 2021 Mar;
12(1):1463.
PMID: 33674590
Kinesin-1 is a processive motor protein that uses ATP-derived energy to transport a variety of intracellular cargoes toward the cell periphery. The ability to visualize and monitor kinesin transport in...
10.
LeGuennec M, Klena N, Aeschlimann G, Hamel V, Guichard P
Curr Opin Struct Biol
. 2020 Nov;
66:58-65.
PMID: 33176264
The centriole is a magnificent molecular assembly of several giga-daltons, one of the largest of the eukaryotic cell, and whose atomic structure remains unsolved to date. However, numerous electron microscopy,...