Nikaia Smith
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Explore the profile of Nikaia Smith including associated specialties, affiliations and a list of published articles.
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42
Citations
3889
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Recent Articles
1.
Bekaddour N, Smith N, Caspar B, Grinberg S, Giorgiutti S, Rodeschini V, et al.
Front Immunol
. 2024 Dec;
15:1490593.
PMID: 39737176
Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by an overactive immune response, particularly involving excessive production of type I interferons. This overproduction is driven by the phosphorylation...
2.
Poisson J, El-Sissy C, Serret-Larmande A, Smith N, Lebraud M, Augy J, et al.
Immun Ageing
. 2024 May;
21(1):28.
PMID: 38715114
Background: Ageing leads to altered immune responses, resulting in higher susceptibility to certain infections in the elderly. Immune ageing is a heterogeneous process also associated with inflammaging, a low-grade chronic...
3.
Bekaddour N, Smith N, Beitz B, Llibre A, Dott T, Baudry A, et al.
Front Immunol
. 2023 Oct;
14:1178172.
PMID: 37822935
Introduction: Among immune cells, activated monocytes play a detrimental role in chronic and viral-induced inflammatory pathologies, particularly in Juvenile Idiopathic Arthritis (JIA), a childhood rheumatoid arthritis (RA) disease. The uncontrolled...
4.
Aquino Y, Bisiaux A, Li Z, ONeill M, Mendoza-Revilla J, Merkling S, et al.
Nature
. 2023 Aug;
621(7977):120-128.
PMID: 37558883
Humans display substantial interindividual clinical variability after SARS-CoV-2 infection, the genetic and immunological basis of which has begun to be deciphered. However, the extent and drivers of population differences in...
5.
Harms M, Smith N, Han M, Gross R, von Maltitz P, Sturzel C, et al.
Sci Adv
. 2023 Jul;
9(27):eadf8251.
PMID: 37406129
Semen is an important vector for sexual HIV-1 transmission. Although CXCR4-tropic (X4) HIV-1 may be present in semen, almost exclusively CCR5-tropic (R5) HIV-1 causes systemic infection after sexual intercourse. To...
6.
Llibre A, Smith N, Rouilly V, Musvosvi M, Nemes E, Posseme C, et al.
Front Immunol
. 2023 Jan;
13:897193.
PMID: 36591308
Tuberculosis (TB) remains a major public health problem and we lack a comprehensive understanding of how () infection impacts host immune responses. We compared the induced immune response to TB...
7.
Smith N, Posseme C, Bondet V, Sugrue J, Townsend L, Charbit B, et al.
Nat Commun
. 2022 Nov;
13(1):7254.
PMID: 36434007
Host immunity to infection with SARS-CoV-2 is highly variable, dictating diverse clinical outcomes ranging from asymptomatic to severe disease and death. We previously reported reduced type I interferon in severe...
8.
Posseme C, Llibre A, Charbit B, Bondet V, Rouilly V, Saint-Andre V, et al.
Cell Rep
. 2022 Jun;
39(13):110989.
PMID: 35767946
The interleukin-12 (IL-12) family comprises the only heterodimeric cytokines mediating diverse functional effects. We previously reported a striking bimodal IL-12p70 response to lipopolysaccharide (LPS) stimulation in healthy donors. Herein, we...
9.
Monel B, Planas D, Grzelak L, Smith N, Robillard N, Staropoli I, et al.
EBioMedicine
. 2021 Oct;
73:103637.
PMID: 34678613
Background: The dynamics of SARS-CoV-2 alpha variant shedding and immune responses at the nasal mucosa remain poorly characterised. Methods: We measured infectious viral release, antibodies and cytokines in 426 PCR+...
10.
Smith N, Goncalves P, Charbit B, Grzelak L, Beretta M, Planchais C, et al.
Nat Immunol
. 2021 Sep;
22(11):1428-1439.
PMID: 34471264
Coordinated local mucosal and systemic immune responses following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection either protect against coronavirus disease 2019 (COVID-19) pathologies or fail, leading to severe clinical...