Nihay Laham-Karam
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Explore the profile of Nihay Laham-Karam including associated specialties, affiliations and a list of published articles.
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31
Citations
451
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Recent Articles
1.
Suoranta T, Laham-Karam N, Yla-Herttuala S
Front Mol Med
. 2024 Aug;
2:1054069.
PMID: 39086961
Adeno-associated virus (AAV) vectors are currently used in four approved gene therapies for Leber congenital amaurosis (Luxturna), spinal muscular atrophy (Zolgensma), aromatic L-amino acid decarboxylase deficiency (Upstaza) and Haemophilia A...
2.
Iori S, DOnofrio C, Laham-Karam N, Mushimiyimana I, Lucatello L, Montanucci L, et al.
Biochem Pharmacol
. 2024 Apr;
224:116231.
PMID: 38648904
In human, the cytochrome P450 3A (CYP3A) subfamily of drug-metabolizing enzymes (DMEs) is responsible for a significant number of phase I reactions, with the CYP3A4 isoform superintending the hepatic and...
3.
Jauhiainen S, Onyeogaziri F, Lazzaroni F, Conze L, Laakkonen J, Laham-Karam N, et al.
Biochim Biophys Acta Mol Basis Dis
. 2024 Mar;
1870(5):167139.
PMID: 38537685
Background: Cerebral cavernous malformation (CCM) is a disease associated with an elevated risk of focal neurological deficits, seizures, and hemorrhagic stroke. The disease has an inflammatory profile and improved knowledge...
4.
Iori S, DOnofrio C, Laham-Karam N, Mushimiyimana I, Lucatello L, Lopparelli R, et al.
Cell Biol Toxicol
. 2024 Mar;
40(1):18.
PMID: 38528259
The cytochrome P450 1A (CYP1A) subfamily of xenobiotic metabolizing enzymes (XMEs) consists of two different isoforms, namely CYP1A1 and CYP1A2, which are highly conserved among species. These two isoenzymes are...
5.
Laham-Karam N, Laakkonen J, Yla-Herttuala S, Aroor A, Jia G, Whaley-Connell A
Cardiorenal Med
. 2024 Feb;
14(1):129-135.
PMID: 38342088
Background: The vascular endothelium serves as a semi-selective permeable barrier as a conduit for transport of fluid, solutes, and various cell populations between the vessel lumen and tissues. The endothelium...
6.
Lampela J, Pajula J, Jarvelainen N, Siimes S, Laham-Karam N, Kivela A, et al.
Sci Rep
. 2024 Jan;
14(1):1467.
PMID: 38233585
Heart failure (HF) is a major burden worldwide, and new therapies are urgently needed. Gene therapy is a promising new approach to treat myocardial diseases. However, current cardiac gene delivery...
7.
Downes N, Niskanen H, Tomas Bosch V, Taipale M, Godiwala M, Vaananen M, et al.
J Biol Chem
. 2023 Sep;
299(11):105291.
PMID: 37748649
Impaired oxygen homeostasis is a frequently encountered pathophysiological factor in multiple complex diseases, including cardiovascular disease and cancer. While the canonical hypoxia response pathway is well characterized, less is known...
8.
Tarvainen S, Wirth G, Juusola G, Hautero O, Kalliokoski K, Sjoros T, et al.
Eur Heart J
. 2023 Aug;
45(4):255-264.
PMID: 37634134
Background And Aims: Clinical management of critical limb-threatening ischaemia (CLTI) is focused on prevention and treatment of atherosclerotic arterial occlusions. The role of microvascular pathology in disease progression is still...
9.
Jauhiainen S, Ilmonen H, Vuola P, Rasinkangas H, Pulkkinen H, Keranen S, et al.
Elife
. 2023 May;
12.
PMID: 37199488
Background: Sporadic venous malformation (VM) and angiomatosis of soft tissue (AST) are benign, congenital vascular anomalies affecting venous vasculature. Depending on the size and location of the lesion, symptoms vary...
10.
Khachigian L, Varcoe R, Suoranta T, Laham-Karam N, Yla-Herttuala S
Arterioscler Thromb Vasc Biol
. 2023 May;
43(6):836-851.
PMID: 37128915
Peripheral artery disease (PAD) is a vascular disorder caused by occlusive atherosclerosis, which commonly impairs blood flow to the lower extremities. The prevalence of PAD is increasing globally with >200...