Nigel W Rayner
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Explore the profile of Nigel W Rayner including associated specialties, affiliations and a list of published articles.
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58
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18400
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Recent Articles
11.
Mahajan A, Spracklen C, Zhang W, Ng M, Petty L, Kitajima H, et al.
Nat Genet
. 2022 May;
54(5):560-572.
PMID: 35551307
We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis...
12.
Graham S, Clarke S, Wu K, Kanoni S, Zajac G, Ramdas S, et al.
Nature
. 2021 Dec;
600(7890):675-679.
PMID: 34887591
Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use. Despite advances in prevention and treatment, in...
13.
Farmaki A, Rayner N, Kafyra M, Matchan A, Ntaoutidou K, Feritoglou P, et al.
Nutrients
. 2019 Dec;
11(12).
PMID: 31847144
The present study describes the geographically isolated Pomak population and its particular dietary patterns in relationship to cardiovascular risk factors. We collected a population-based cohort in a cross-sectional study, with...
14.
Gilly A, Suveges D, Kuchenbaecker K, Pollard M, Southam L, Hatzikotoulas K, et al.
Nat Commun
. 2018 Dec;
9(1):5460.
PMID: 30568165
The original version of this Article contained an error in Fig. 2. In panel a, the two legend items "rare" and "common" were inadvertently swapped. This has been corrected in...
15.
Gilly A, Suveges D, Kuchenbaecker K, Pollard M, Southam L, Hatzikotoulas K, et al.
Nat Commun
. 2018 Nov;
9(1):4674.
PMID: 30405126
The role of rare variants in complex traits remains uncharted. Here, we conduct deep whole genome sequencing of 1457 individuals from an isolated population, and test for rare variant burdens...
16.
Mamakou V, Hackinger S, Zengini E, Tsompanaki E, Marouli E, Serafetinidis I, et al.
BMC Psychiatry
. 2018 Aug;
18(1):249.
PMID: 30071838
Background: Schizophrenia (SCZ) is associated with increased risk of type 2 diabetes (T2D). The potential diabetogenic effect of concomitant application of psychotropic treatment classes in patients with SCZ has not...
17.
Scott R, Scott L, Magi R, Marullo L, Gaulton K, Kaakinen M, et al.
Diabetes
. 2017 Jun;
66(11):2888-2902.
PMID: 28566273
To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects of European...
18.
Tachmazidou I, Suveges D, Min J, Ritchie G, Steinberg J, Walter K, et al.
Am J Hum Genet
. 2017 May;
100(6):865-884.
PMID: 28552196
Deep sequence-based imputation can enhance the discovery power of genome-wide association studies by assessing previously unexplored variation across the common- and low-frequency spectra. We applied a hybrid whole-genome sequencing (WGS)...
19.
Southam L, Gilly A, Suveges D, Farmaki A, Schwartzentruber J, Tachmazidou I, et al.
Nat Commun
. 2017 May;
8:15606.
PMID: 28548082
Next-generation association studies can be empowered by sequence-based imputation and by studying founder populations. Here we report ∼9.5 million variants from whole-genome sequencing (WGS) of a Cretan-isolated population, and show...
20.
Ried J, Jeff M J, Chu A, Bragg-Gresham J, Dongen J, Huffman J, et al.
Nat Commun
. 2016 Nov;
7:13357.
PMID: 27876822
Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that...