Nicole Tubbs
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Explore the profile of Nicole Tubbs including associated specialties, affiliations and a list of published articles.
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12
Citations
78
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Recent Articles
1.
Treatment of life-threatening H2S intoxication: Lessons from the trapping agent tetranitrocobinamide
Haouzi P, MacCann M, Brenner M, Mahon S, Bebarta V, Chan A, et al.
Environ Toxicol Pharmacol
. 2022 Oct;
96:103998.
PMID: 36228991
We sought to evaluate the efficacy of trapping free hydrogen sulfide (HS) following severe HS intoxication. Sodium hydrosulfide solution (NaHS, 20 mg/kg) was administered intraperitoneally in 69 freely moving rats....
2.
Haouzi P, Tubbs N
J Appl Physiol (1985)
. 2022 Apr;
132(6):1407-1422.
PMID: 35421320
The objective of our study was to establish in sedated rats the consequences of high-dose fentanyl-induced acute muscle rigidity on the mechanical properties of the respiratory system and on the...
3.
Haouzi P, McCann M, Tubbs N
J Neurophysiol
. 2021 Mar;
125(4):1396-1407.
PMID: 33656934
We have investigated the potential acute desensitizing role of the β arrestin 2 (β-arr2) pathway on the ventilatory depression produced by levels of fentanyl ranging from analgesic to life-threatening (0.1...
4.
Haouzi P, McCann M, Tubbs N
Toxicol Rep
. 2020 Nov;
7:1459-1464.
PMID: 33194557
We have determined the effects of azure B (AzB), the main demethylated metabolite of methylene blue (MB), on a model of lethal cyanide intoxication. Our rationale was the following: AzB...
5.
Haouzi P, McCann M, Wang J, Zhang X, Song J, Sariyer I, et al.
Ann N Y Acad Sci
. 2020 May;
1479(1):108-121.
PMID: 32374444
The aim of the present study was to determine whether methylene blue (MB) could directly oppose the neurological toxicity of a lethal cyanide (CN) intoxication. KCN, infused at the rate...
6.
Haouzi P, Mellen N, McCann M, Sternick M, Guck D, Tubbs N
Respir Physiol Neurobiol
. 2020 Mar;
277:103428.
PMID: 32151709
Breathing resumes within one to two minutes following fentanyl overdose induced apnea in spontaneously breathing rats. As this regular rhythm is produced at a time wherein fentanyl concentrations and receptor...
7.
Haouzi P, Guck D, McCann M, Sternick M, Sonobe T, Tubbs N
Anesthesiology
. 2020 Feb;
132(5):1138-1150.
PMID: 32044798
Background: As severe acute hypoxemia produces a rapid inhibition of the respiratory neuronal activity through a nonopioid mechanism, we have investigated in adult rats the effects of hypoxemia after fentanyl...
8.
Haouzi P, McCann M, Tubbs N, Judenherc-Haouzi A, Cheung J, Bouillaud F
Toxicol Sci
. 2019 Mar;
170(1):82-94.
PMID: 30907955
Our study was aimed at (1) determining the efficacy of the dye methylene blue (MB), following a rapidly lethal cyanide (CN) intoxication in un-sedated rats; (2) clarifying some of the...
9.
Haouzi P, Tubbs N, Cheung J, Judenherc-Haouzi A
Toxicol Sci
. 2018 Dec;
168(2):443-459.
PMID: 30590764
Exposure to toxic levels of hydrogen sulfide (H2S) produces an acute cardiac depression that can be rapidly fatal. We sought to characterize the time course of the cardiac effects produced...
10.
Haouzi P, Gueguinou M, Sonobe T, Judenherc-Haouzi A, Tubbs N, Trebak M, et al.
Clin Toxicol (Phila)
. 2018 Feb;
56(9):828-840.
PMID: 29451035
Background: Although methylene blue (MB) had long been proposed to counteract the effects of cyanide (CN) intoxication, research on its mechanisms of action and efficacy has been abandoned for decades....