Nicolas Vinckenbosch
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Explore the profile of Nicolas Vinckenbosch including associated specialties, affiliations and a list of published articles.
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12
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Recent Articles
1.
Huerta-Sanchez E, Jin X, Asan , Bianba Z, Peter B, Vinckenbosch N, et al.
Nature
. 2014 Jul;
512(7513):194-7.
PMID: 25043035
As modern humans migrated out of Africa, they encountered many new environmental conditions, including greater temperature extremes, different pathogens and higher altitudes. These diverse environments are likely to have acted...
2.
Lohmueller K, Albrechtsen A, Li Y, Kim S, Korneliussen T, Vinckenbosch N, et al.
PLoS Genet
. 2011 Oct;
7(10):e1002326.
PMID: 22022285
A major question in evolutionary biology is how natural selection has shaped patterns of genetic variation across the human genome. Previous work has documented a reduction in genetic diversity in...
3.
Li Y, Vinckenbosch N, Tian G, Huerta-Sanchez E, Jiang T, Jiang H, et al.
Nat Genet
. 2010 Oct;
42(11):969-72.
PMID: 20890277
Targeted capture combined with massively parallel exome sequencing is a promising approach to identify genetic variants implicated in human traits. We report exome sequencing of 200 individuals from Denmark with...
4.
Yi X, Liang Y, Huerta-Sanchez E, Jin X, Cuo Z, Pool J, et al.
Science
. 2010 Jul;
329(5987):75-8.
PMID: 20595611
Residents of the Tibetan Plateau show heritable adaptations to extreme altitude. We sequenced 50 exomes of ethnic Tibetans, encompassing coding sequences of 92% of human genes, with an average coverage...
5.
Potrzebowski L, Vinckenbosch N, Kaessmann H
Trends Genet
. 2009 Nov;
26(1):1-4.
PMID: 19931933
Recent studies have revealed that our sex chromosomes differentiated relatively recently from ancestral autosomes in the common ancestor of placental and marsupial mammals (therians). Here, we show that the therian...
6.
Henrichsen C, Vinckenbosch N, Zollner S, Chaignat E, Pradervand S, Schutz F, et al.
Nat Genet
. 2009 Mar;
41(4):424-9.
PMID: 19270705
Copy number variation (CNV) is a key source of genetic diversity, but a comprehensive understanding of its phenotypic effect is only beginning to emerge. We have generated a CNV map...
7.
Kaessmann H, Vinckenbosch N, Long M
Nat Rev Genet
. 2008 Nov;
10(1):19-31.
PMID: 19030023
Gene copies that stem from the mRNAs of parental source genes have long been viewed as evolutionary dead-ends with little biological relevance. Here we review a range of recent studies...
8.
Potrzebowski L, Vinckenbosch N, Marques A, Chalmel F, Jegou B, Kaessmann H
PLoS Biol
. 2008 Apr;
6(4):e80.
PMID: 18384235
Mammalian sex chromosomes stem from ancestral autosomes and have substantially differentiated. It was shown that X-linked genes have generated duplicate intronless gene copies (retrogenes) on autosomes due to this differentiation....
9.
Marques A, Vinckenbosch N, Brawand D, Kaessmann H
Genome Biol
. 2008 Mar;
9(3):R54.
PMID: 18336717
Background: Gene duplication is the primary source of new genes with novel or altered functions. It is known that duplicates may obtain these new functional roles by evolving divergent expression...
10.
Vinckenbosch N, Dupanloup I, Kaessmann H
Proc Natl Acad Sci U S A
. 2006 Feb;
103(9):3220-5.
PMID: 16492757
Given that retroposed copies of genes are presumed to lack the regulatory elements required for their expression, retroposition has long been considered a mechanism without functional relevance. However, through an...