Nicolas G Shealy
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Explore the profile of Nicolas G Shealy including associated specialties, affiliations and a list of published articles.
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10
Citations
183
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Recent Articles
1.
Yoo W, Shealy N, Zieba J, Torres T, Baltagulov M, Thomas J, et al.
Cell Host Microbe
. 2024 May;
32(6):887-899.e6.
PMID: 38806059
Inflammation boosts the availability of electron acceptors in the intestinal lumen, creating a favorable niche for pathogenic Enterobacteriaceae. However, the mechanisms linking intestinal inflammation-mediated changes in luminal metabolites and pathogen...
2.
Shealy N, Baltagulov M, Byndloss M
Mol Microbiol
. 2024 May;
122(3):304-312.
PMID: 38690771
The small intestine represents a complex and understudied gut niche with significant implications for human health. Indeed, many infectious and non-infectious diseases center within the small intestine and present similar...
3.
Shelton C, Sing E, Mo J, Shealy N, Yoo W, Thomas J, et al.
Cell Host Microbe
. 2023 Oct;
31(10):1604-1619.e10.
PMID: 37794592
The mechanisms by which the early-life microbiota protects against environmental factors that promote childhood obesity remain largely unknown. Using a mouse model in which young mice are simultaneously exposed to...
4.
Spiga L, Fansler R, Perera Y, Shealy N, Munneke M, David H, et al.
Cell Host Microbe
. 2023 Sep;
31(10):1639-1654.e10.
PMID: 37776864
During intestinal inflammation, host nutritional immunity starves microbes of essential micronutrients, such as iron. Pathogens scavenge iron using siderophores, including enterobactin; however, this strategy is counteracted by host protein lipocalin-2,...
5.
Spiga L, Fansler R, Perera Y, Shealy N, Munneke M, Torres T, et al.
bioRxiv
. 2023 Jul;
PMID: 37425782
During intestinal inflammation, host nutritional immunity starves microbes of essential micronutrients such as iron. Pathogens scavenge iron using siderophores, which is counteracted by the host using lipocalin-2, a protein that...
6.
Lunnemann H, Shealy N, Reyzer M, Shupe J, Green E, Siddiqi U, et al.
Gut Microbes
. 2023 Mar;
15(1):2185029.
PMID: 36872510
The mouse cecum has emerged as a model system for studying microbe-host interactions, immunoregulatory functions of the microbiome, and metabolic contributions of gut bacteria. Too often, the cecum is falsely...
7.
Shelton C, Yoo W, Shealy N, Torres T, Zieba J, Calcutt M, et al.
Cell Rep
. 2022 Jan;
38(1):110180.
PMID: 34986344
The gut microbiota benefits the host by limiting enteric pathogen expansion (colonization resistance), partially via the production of inhibitory metabolites. Propionate, a short-chain fatty acid produced by microbiota members, is...
8.
Shealy N, Byndloss M
Cell Host Microbe
. 2021 Nov;
29(11):1606-1608.
PMID: 34762826
Have you ever caught family members eating the last piece of your Halloween candy? In this issue of Cell Host & Microbe, Osbelt et al. and Eberl et al. demonstrate...
9.
Shealy N, Yoo W, Byndloss M
Curr Opin Microbiol
. 2021 Oct;
64:82-90.
PMID: 34688039
The intestine is home to a large and complex bacterial ecosystem (microbiota), which performs multiple beneficial functions for the host, including immune education, nutrition, and protection against invasion by enteric...
10.
Yoo W, Zieba J, Foegeding N, Torres T, Shelton C, Shealy N, et al.
Science
. 2021 Aug;
373(6556):813-818.
PMID: 34385401
A Western-style, high-fat diet promotes cardiovascular disease, in part because it is rich in choline, which is converted to trimethylamine (TMA) by the gut microbiota. However, whether diet-induced changes in...