Nicolas Chomont
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Explore the profile of Nicolas Chomont including associated specialties, affiliations and a list of published articles.
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207
Citations
10831
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Recent Articles
1.
Mitchell J, Buranapraditkun S, Gantner P, Takata H, Dietze K, Nguessan K, et al.
J Virol
. 2025 Feb;
:e0153224.
PMID: 39932316
Importance: Early initiation of antiretroviral therapy (ART) is important to limit the seeding of the long-lasting HIV-1 reservoir; however, it also precludes the development of HIV-specific antibodies that can help...
2.
Marichannegowda M, Setua S, Bose M, Sanders-Buell E, King D, Zemil M, et al.
EBioMedicine
. 2024 Oct;
109:105410.
PMID: 39427414
Background: Nearly all transmitted/founder (T/F) HIV-1 are CCR5 (R5)-tropic. While previous evidence suggested that CXCR4 (X4)-tropic HIV-1 are transmissible, virus detection and characterization were not at the earliest stages of...
3.
Howard J, Levinger C, Deletsu S, Fromentin R, Chomont N, Bosque A
PLoS Pathog
. 2024 Oct;
20(10):e1012601.
PMID: 39401241
Development of novel therapeutic strategies that reactivate latent HIV and sensitize reactivated cells to apoptosis is crucial towards elimination of the latent viral reservoir. Among the clinically relevant latency reversing...
4.
Fert A, Richard J, Raymond Marchand L, Planas D, Routy J, Chomont N, et al.
iScience
. 2024 Sep;
27(9):110670.
PMID: 39252967
The mechanistic target of rapamycin (mTOR) positively regulates multiple steps of the HIV-1 replication cycle. We previously reported that a 12-week supplementation of antiretroviral therapy (ART) with metformin, an indirect...
5.
Yero A, Goulet J, Shi T, Costiniuk C, Routy J, Tremblay C, et al.
EBioMedicine
. 2024 Aug;
107:105274.
PMID: 39178742
Background: Despite successful antiretroviral therapy (ART), frequencies and immunological functions of memory CCR6 Th17-polarised CD4 T-cells are not fully restored in people with HIV (PWH). Moreover, long-lived Th17 cells contribute...
6.
Royston L, Jary A, Berini C, Mabanga T, Lin J, Pagliuzza A, et al.
Open Forum Infect Dis
. 2024 Aug;
11(8):ofae404.
PMID: 39100526
Background: Reemergence of human herpesvirus 8 (HHV-8)-induced Kaposi sarcoma (KS) in people living with HIV (PLWH) despite antiretroviral therapy (ART) poses a clinical challenge because they already have favorable CD4...
7.
Brunet-Ratnasingham E, Morin S, Randolph H, Labrecque M, Belair J, Lima-Barbosa R, et al.
Nat Commun
. 2024 May;
15(1):4177.
PMID: 38755196
Plasma RNAemia, delayed antibody responses and inflammation predict COVID-19 outcomes, but the mechanisms underlying these immunovirological patterns are poorly understood. We profile 782 longitudinal plasma samples from 318 hospitalized patients...
8.
Fournelle D, Mostefai F, Brunet-Ratnasingham E, Poujol R, Grenier J, Galvez J, et al.
Viruses
. 2024 Mar;
16(3).
PMID: 38543708
Throughout the SARS-CoV-2 pandemic, several variants of concern (VOCs) have been identified, many of which share recurrent mutations in the spike glycoprotein's receptor-binding domain (RBD). This region coincides with known...
9.
Fert A, Richard J, Raymond Marchand L, Planas D, Routy J, Chomont N, et al.
bioRxiv
. 2024 Mar;
PMID: 38464135
The mechanistic target of rapamycin (mTOR) positively regulates multiple steps of the HIV-1 replication cycle. We previously reported that a 12-weeks supplementation of antiretroviral therapy (ART) with metformin, an indirect...
10.
Rhodes J, Aumon A, Morin S, Girard M, Larochelle C, Brunet-Ratnasingham E, et al.
bioRxiv
. 2024 Jan;
PMID: 38293135
Dimensionality reduction-based data visualization is pivotal in comprehending complex biological data. The most common methods, such as PHATE, t-SNE, and UMAP, are unsupervised and therefore reflect the dominant structure in...