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Nicola Flowers

Explore the profile of Nicola Flowers including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 139
Followers 0
Related Specialties
General Medicine
Gynecology & Obstetrics
Biochemistry
Top 10 Co-Authors
Mark D Pertile
Darcy Vavrek
Martin B Delatycki
Paul A James
Kristen Meier
Javier Miguelez
Joanne Kelley
Erik A Sistermans
Peter Jurcevic
Sarah L Kinnings
Published In
Prenat Diagn
Eur J Hum Genet
BMC Med
Clin Chem
Sci Transl Med
Affiliations
Soon will be listed here.
Recent Articles
1.
Performance of a cell-free DNA prenatal screening test, choice of prenatal procedure, and chromosome conditions identified during pregnancy after low-risk cell-free DNA screening
Scarff K, Flowers N, Love C, Archibald A, Hunt C, Giouzeppos O, et al.
Prenat Diagn . 2023 Jan; 43(2):213-225. PMID: 36617980
Objectives: To evaluate the performance of cell-free DNA (cfDNA) screening for common fetal aneuploidies, choice of prenatal procedure, and chromosome conditions identified during pregnancy after low-risk cfDNA screening. Method: A...
2.
Cancer Diagnoses Following Abnormal Noninvasive Prenatal Testing: A Case Series, Literature Review, and Proposed Management Model
Dow E, Freimund A, Smith K, Hicks R, Jurcevic P, Shackleton M, et al.
JCO Precis Oncol . 2022 Jan; 5:1001-1012. PMID: 34994626
Noninvasive prenatal testing (NIPT) is a screening test for fetal chromosomal aneuploidy using cell-free DNA derived from maternal blood. It has been rapidly accepted into obstetric practice because of its...
3.
Performance of a Paired-End Sequencing-Based Noninvasive Prenatal Screening Test in the Detection of Genome-Wide Fetal Chromosomal Anomalies
Pertile M, Flowers N, Vavrek D, Andrews D, Kalista T, Craig A, et al.
Clin Chem . 2021 Jun; 67(9):1210-1219. PMID: 34077512
Background: Noninvasive prenatal tests (NIPTs) detect fetal chromosomal anomalies with high clinical sensitivity and specificity. We examined the performance of a paired-end sequencing-based NIPT in the detection of genome-wide fetal...
4.
Isochromosome 21q is overrepresented among false-negative cell-free DNA prenatal screening results involving Down syndrome
Amsterdam K, Page-Christiaens L, Flowers N, Bonifacio M, Ellis K, Vogel I, et al.
Eur J Hum Genet . 2018 Jun; 26(10):1490-1496. PMID: 29899373
False-negative cell-free DNA (cfDNA) screening results involving Down syndrome are rare, but have high clinical impact on patients and their healthcare providers. Understanding the biology behind these results may allow...
5.
Rare autosomal trisomies, revealed by maternal plasma DNA sequencing, suggest increased risk of feto-placental disease
Pertile M, Halks-Miller M, Flowers N, Barbacioru C, Kinnings S, Vavrek D, et al.
Sci Transl Med . 2017 Sep; 9(405). PMID: 28855395
Whole-genome sequencing (WGS) of maternal plasma cell-free DNA (cfDNA) can potentially evaluate all 24 chromosomes to identify abnormalities of the placenta, fetus, or pregnant woman. Current bioinformatics algorithms typically only...
6.
Abnormal plasma DNA profiles in early ovarian cancer using a non-invasive prenatal testing platform: implications for cancer screening
Cohen P, Flowers N, Tong S, Hannan N, Pertile M, Hui L
BMC Med . 2016 Aug; 14(1):126. PMID: 27558279
Background: Non-invasive prenatal testing (NIPT) identifies fetal aneuploidy by sequencing cell-free DNA in the maternal plasma. Pre-symptomatic maternal malignancies have been incidentally detected during NIPT based on abnormal genomic profiles....
7.
Maternal mosaicism for a large segmental duplication of 18q as a secondary finding following non-invasive prenatal testing and implications for test accuracy
Flowers N, Kelley J, Sigurjonsson S, Bruno D, Pertile M
Prenat Diagn . 2015 Jul; 35(10):986-9. PMID: 26151667
No abstract available.