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Nicholas P Williams

Explore the profile of Nicholas P Williams including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 274
Followers 0
Related Specialties
Pulmonary Medicine
General Medicine
Top 10 Co-Authors
Karl J Staples
Tom M A Wilkinson
Jeanne-Marie Devaster
Stuart C Clarke
Emmanuel Aris
Andrew C Tuck
Kristoffer K Ostridge
Viktoriya L Kim
Ngaire A Coombs
Andrew Tuck
Published In
Respir Res
Int J Chron Obstruct Pulmon Dis
Eur Respir J
ERJ Open Res
Thorax
Affiliations
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Recent Articles
1.
Pulmonary EV miRNA profiles identify disease and distinct inflammatory endotypes in COPD
Burke H, Cellura D, Freeman A, Hicks A, Ostridge K, Watson A, et al.
Front Med (Lausanne) . 2023 Jan; 9:1039702. PMID: 36590967
Introduction: Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition without effective disease modifying therapies. Identification of novel inflammatory endotype markers such as extracellular vesicles (EVs), which are important intercellular...
2.
Drivers of year-to-year variation in exacerbation frequency of COPD: analysis of the AERIS cohort
Wilkinson T, Aris E, Bourne S, Clarke S, Peeters M, Pascal T, et al.
ERJ Open Res . 2019 Mar; 5(1). PMID: 30815467
The association between exacerbation aetiology and exacerbation frequency is poorly understood. We analysed 2-year follow-up data from a prospective observational study of patients with chronic obstructive pulmonary disease (COPD) (www.clinicaltrials.gov...
3.
Impact of radiologically stratified exacerbations: insights into pneumonia aetiology in COPD
Williams N, Ostridge K, Devaster J, Kim V, Coombs N, Bourne S, et al.
Respir Res . 2018 Jul; 19(1):143. PMID: 30055608
Background: COPD patients have increased risk of developing pneumonia, which is associated with poor outcomes. It can be symptomatically indistinguishable from exacerbations, making diagnosis challenging. Studies of pneumonia in COPD...
4.
Relationship of CT-quantified emphysema, small airways disease and bronchial wall dimensions with physiological, inflammatory and infective measures in COPD
Ostridge K, Williams N, Kim V, Harden S, Bourne S, Clarke S, et al.
Respir Res . 2018 Feb; 19(1):31. PMID: 29458372
Background: COPD is a complex, heterogeneous disease characterised by progressive development of airflow limitation. Spirometry provides little information about key aspects of pathology and is poorly related to clinical outcome,...
5.
Longitudinal profiling of the lung microbiome in the AERIS study demonstrates repeatability of bacterial and eosinophilic COPD exacerbations
Mayhew D, Devos N, Lambert C, Brown J, Clarke S, Kim V, et al.
Thorax . 2018 Feb; 73(5):422-430. PMID: 29386298
Background: Alterations in the composition of the lung microbiome associated with adverse clinical outcomes, known as dysbiosis, have been implicated with disease severity and exacerbations in COPD. Objective: To characterise...
6.
Impact and associations of eosinophilic inflammation in COPD: analysis of the AERIS cohort
Kim V, Coombs N, Staples K, Ostridge K, Williams N, Wootton S, et al.
Eur Respir J . 2017 Oct; 50(4). PMID: 29025891
Eosinophilic inflammation in chronic obstructive pulmonary disease (COPD) predicts response to treatment, especially corticosteroids. We studied the nature of eosinophilic inflammation in COPD prospectively to examine the stability of this...
7.
Seasonality, risk factors and burden of community-acquired pneumonia in COPD patients: a population database study using linked health care records
Williams N, Coombs N, Johnson M, Josephs L, Rigge L, Staples K, et al.
Int J Chron Obstruct Pulmon Dis . 2017 Feb; 12:313-322. PMID: 28176888
Background: Community-acquired pneumonia (CAP) is more common in patients with COPD than in the adult general population, with studies of hospitalized CAP patients consistently reporting COPD as a frequent comorbidity....