Nicholas M Provine
Overview
Explore the profile of Nicholas M Provine including associated specialties, affiliations and a list of published articles.
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45
Citations
1198
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Recent Articles
1.
Yong L, Hutchings C, Barnes E, Klenerman P, Provine N
Eur J Immunol
. 2024 Nov;
55(1):e202451142.
PMID: 39604225
CD4 T cells have been established as central orchestrators of cellular and humoral immune responses to infection or vaccination. However, the need for CD4 T cell help to generate primary...
2.
Al-Diwani A, Agrawal D, Sheerin F, Board C, Irani S, Pollock K, et al.
Curr Protoc
. 2024 Nov;
4(11):e70063.
PMID: 39579041
Lymph nodes (LNs) are specialized secondary lymphoid tissues essential to the priming and maintenance of adaptive immune responses, including the B cell germinal center response; thus, they are central to...
3.
Oliver A, Huang N, Bartolome-Casado R, Li R, Koplev S, Nilsen H, et al.
Nature
. 2024 Nov;
635(8039):699-707.
PMID: 39567783
The gastrointestinal tract is a multi-organ system crucial for efficient nutrient uptake and barrier immunity. Advances in genomics and a surge in gastrointestinal diseases has fuelled efforts to catalogue cells...
4.
Al-Diwani A, Provine N, Murchison A, Laban R, Swann O, Koychev I, et al.
Brain
. 2024 Oct;
148(2):394-400.
PMID: 39432679
In animal models, brain neurodegeneration biomarkers drain into cervical lymph nodes (CLNs), and this drainage function is reduced with ageing. If this occurred in humans, CLNs may provide a readily...
5.
Amini A, Klenerman P, Provine N
Curr Opin Virol
. 2024 Jun;
67:101412.
PMID: 38838550
Mucosal-associated invariant T (MAIT) cells are an unconventional T cell population that are highly abundant in humans. They possess a semi-invariant T cell receptor (TCR) that recognises microbial metabolites formed...
6.
Provine N, Al-Diwani A, Agarwal D, Dooley K, Heslington A, Murchison A, et al.
Eur J Immunol
. 2024 Feb;
54(5):e2350872.
PMID: 38388988
Lymph node (LN) fine needle aspiration (LN FNA) represents a powerful technique for minimally invasive sampling of human LNs in vivo and has been used effectively to directly study aspects...
7.
Murray S, Pose E, Wittner M, Londono M, Schaub G, Cook J, et al.
J Hepatol
. 2023 Oct;
80(1):109-123.
PMID: 37863203
Background & Aims: Comparative assessments of immunogenicity following different COVID-19 vaccines in patients with distinct liver diseases are lacking. SARS-CoV-2-specific T-cell and antibody responses were evaluated longitudinally after one to...
8.
Garner L, Amini A, FitzPatrick M, Lett M, Hess G, Filipowicz Sinnreich M, et al.
Nat Immunol
. 2023 Aug;
24(9):1565-1578.
PMID: 37580605
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognize microbial metabolites through a semi-invariant T cell receptor (TCR). Major questions remain regarding the extent of human MAIT cell...
9.
Provine N
Immunol Cell Biol
. 2023 May;
101(6):470-472.
PMID: 37137689
In this article, I discuss recent work by Pankhurst et al. They found that MAIT cells can serve as a cellular adjuvant to boost immunity to a protein adjuvant. Intranasal...
10.
Liu G, Barczak W, Ni Lee L, Shrestha A, Provine N, Albayrak G, et al.
Commun Biol
. 2023 Jan;
6(1):102.
PMID: 36702861
Protein acetylation plays a key role in regulating cellular processes and is subject to aberrant control in diverse pathologies. Although histone deacetylase (HDAC) inhibitors are approved drugs for certain cancers,...