Nicholas M Dean
Overview
Explore the profile of Nicholas M Dean including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
1806
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Recent Articles
1.
Theobald B, Bonness K, Musiyenko A, Andrews J, Urban G, Huang X, et al.
Mol Cancer Res
. 2013 May;
11(8):845-55.
PMID: 23671329
Unlabelled: Fostriecin is a natural product purified from Sterptomyces extracts with antitumor activity sufficient to warrant human clinical trials. Unfortunately, difficulties associated with supply and stable drug formulation stalled further...
2.
Sisco M, Kryger Z, OShaughnessy K, Kim P, Schultz G, Ding X, et al.
Wound Repair Regen
. 2009 Jan;
16(5):661-73.
PMID: 19128261
Augmented expression of connective tissue growth factor (CTGF/CCN2) is observed in healing wounds and in a variety of fibrotic disorders. It appears to enhance many of the effects of transforming...
3.
Graff J, Konicek B, Vincent T, Lynch R, Monteith D, Weir S, et al.
J Clin Invest
. 2007 Sep;
117(9):2638-48.
PMID: 17786246
Expression of eukaryotic translation initiation factor 4E (eIF4E) is commonly elevated in human and experimental cancers, promoting angiogenesis and tumor growth. Elevated eIF4E levels selectively increase translation of growth factors...
4.
Kim Y, Yoon J, Xiao X, Dean N, Monia B, Marcusson E
Cancer Res
. 2007 Apr;
67(8):3583-93.
PMID: 17440069
The sonic hedgehog (Shh) pathway contributes to the initiation and progression of tumors with various origins when aberrantly activated. In this study, we investigated if the Shh pathway is important...
5.
Bonness K, Aragon I, Rutland B, Ofori-Acquah S, Dean N, Honkanen R
Mol Cancer Ther
. 2006 Nov;
5(11):2727-36.
PMID: 17121919
Cantharidin, a natural vesicant, inhibits the activity of several PPP family phosphatases, displays antitumor activity, and induces apoptosis in many types of tumor cells. However, the molecular mechanisms underlying the...
6.
Carter B, Mak D, Shi Y, Schober W, Wang R, Konopleva M, et al.
Cell Cycle
. 2006 Sep;
5(19):2223-9.
PMID: 16969080
Patients with blast crisis (BC) CML frequently become resistant to Imatinib, a Bcr-Abl tyrosine kinase-targeting agent. Eg5, a microtubule-associated motor protein has been described to be highly expressed in BC...
7.
Koller E, Propp S, Murray H, Lima W, Bhat B, Prakash T, et al.
Nucleic Acids Res
. 2006 Sep;
34(16):4467-76.
PMID: 16945958
Short interfering RNAs (siRNA) guide degradation of target RNA by the RNA-induced silencing complex (RISC). The use of siRNA in animals is limited partially due to the short half-life of...
8.
Vickers T, Zhang H, Graham M, Lemonidis K, Zhao C, Dean N
J Immunol
. 2006 Mar;
176(6):3652-61.
PMID: 16517734
A number of proinflammatory cytokines, including IL-1beta, signal through the adaptor protein MyD88. This signaling leads to phosphorylation of IL-1R-associated kinase-1 (IRAK-1) and, ultimately, activation of the NF-kappaB transcription factor....
9.
Koller E, Propp S, Zhang H, Zhao C, Xiao X, Chang M, et al.
Cancer Res
. 2006 Feb;
66(4):2059-66.
PMID: 16489005
A library of 2'-methoxyethyl-modified antisense oligonucleotides (2'MOE ASO) targeting 1,510 different genes has been developed, validated, and used to identify cell cycle regulatory genes. The most effective molecular target identified...
10.
Perera R, Koo S, Bennett C, Dean N, Gupta N, Qin J, et al.
J Cell Biochem
. 2006 Jan;
98(2):394-408.
PMID: 16440318
Epidermal keratinocytes (KCs) undergo highly orchestrated morphological and molecular changes during transition from proliferative compartment into growth arrested early and late differentiation layers, prior to dying in outermost cornified layers...