Nicholas M Chesarino
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Explore the profile of Nicholas M Chesarino including associated specialties, affiliations and a list of published articles.
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16
Citations
540
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Recent Articles
1.
Li Y, Langley C, Azumaya C, Echeverria I, Chesarino N, Emerman M, et al.
Nature
. 2023 Feb;
615(7953):728-733.
PMID: 36754086
The APOBEC3 (A3) proteins are host antiviral cellular proteins that hypermutate the viral genome of diverse viral families. In retroviruses, this process requires A3 packaging into viral particles. The lentiviruses...
2.
Chesarino N, Emerman M
J Virol
. 2021 Dec;
96(4):e0207121.
PMID: 34908448
APOBEC3G (A3G) is a host-encoded cytidine deaminase that potently restricts retroviruses such as HIV-1 and depends on its ability to package into virions. As a consequence of this, HIV-1 protein...
3.
Kaake R, Echeverria I, Kim S, Von Dollen J, Chesarino N, Feng Y, et al.
Mol Cell Proteomics
. 2021 Aug;
20:100132.
PMID: 34389466
Structural analysis of host-pathogen protein complexes remains challenging, largely due to their structural heterogeneity. Here, we describe a pipeline for the structural characterization of these complexes using integrative structure modeling...
4.
Chesarino N, Emerman M
Viruses
. 2020 Apr;
12(4).
PMID: 32235597
The APOBEC3 family of cytidine deaminases are an important part of the host innate immune defense against endogenous retroelements and retroviruses like Human Immunodeficiency Virus (HIV). APOBEC3H (A3H) is the...
5.
Binning J, Chesarino N, Emerman M, Gross J
Cell Host Microbe
. 2019 Dec;
26(6):739-747.e4.
PMID: 31830442
Primate lentiviruses encode a Vif protein that counteracts the host antiviral APOBEC3 (A3) family members. The adaptation of Vif to species-specific A3 determinants is a critical event that allowed the...
6.
Kenney A, McMichael T, Imas A, Chesarino N, Zhang L, Dorn L, et al.
Proc Natl Acad Sci U S A
. 2019 Aug;
116(37):18607-18612.
PMID: 31451661
Influenza virus can disseminate from the lungs to the heart in severe infections and can induce cardiac pathology, but this has been difficult to study due to a lack of...
7.
Chesarino N, Compton A, McMichael T, Kenney A, Zhang L, Soewarna V, et al.
EMBO Rep
. 2017 Aug;
18(10):1740-1751.
PMID: 28835547
Interferon-induced transmembrane protein 3 (IFITM3) is a cellular factor that blocks virus fusion with cell membranes. IFITM3 has been suggested to alter membrane curvature and fluidity, though its exact mechanism...
8.
Johansen J, Bohunicka M, Lukesova A, Hrckova K, Vaccarino M, Chesarino N
J Phycol
. 2016 Mar;
50(1):187-202.
PMID: 26988018
Twenty-six strains morphologically identified as Cylindrospermum as well as the closely related taxon Cronbergia siamensis were examined microscopically as well as phylogenetically using sequence data for the 16S rRNA gene...
9.
Chesarino N, McMichael T, Yount J
PLoS Pathog
. 2015 Aug;
11(8):e1005095.
PMID: 26263374
Interferon (IFN)-induced transmembrane protein 3 (IFITM3) is a cell-intrinsic factor that limits influenza virus infections. We previously showed that IFITM3 degradation is increased by its ubiquitination, though the ubiquitin ligase...
10.
Melvin W, McMichael T, Chesarino N, Hach J, Yount J
Viruses
. 2015 Jun;
7(6):3035-52.
PMID: 26075508
Interferon induced transmembrane proteins (IFITMs) found in vertebrates restrict infections by specific viruses. IFITM3 is known to be essential for restriction of influenza virus infections in both mice and humans....