Nicholas J A Webb
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Explore the profile of Nicholas J A Webb including associated specialties, affiliations and a list of published articles.
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84
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1243
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Recent Articles
1.
Kavanagh D, Barratt J, Schubart A, Webb N, Meier M, Fakhouri F
Front Immunol
. 2025 Mar;
16:1537974.
PMID: 40028332
The complement system, consisting of three initiating pathways-classical, lectin and alternative, is an important part of innate immunity. Dysregulation of the complement system is implicated in the pathogenesis of several...
2.
Nester C, Eisenberger U, Karras A, le Quintrec M, Lightstone L, Praga M, et al.
Kidney Int Rep
. 2025 Feb;
10(2):432-446.
PMID: 39990880
Introduction: C3 glomerulopathy (C3G) is a complex, chronic, ultra rare, progressive primary glomerulonephritis, resulting from alternative complement pathway overactivation, leading to kidney failure in most patients, and frequent recurrence in...
3.
Patry C, Webb N, Meier M, Pape L, Fichtner A, Hocker B, et al.
Pediatr Transplant
. 2025 Feb;
29(2):e70048.
PMID: 39989336
Background: Approximately 50% of patients with chronic kidney disease due to C3 glomerulopathy (C3G) or primary immune-complex membranoproliferative glomerulonephritis (IC-MPGN) will require dialysis and/or kidney transplantation (KTx) within the first...
4.
Patry C, Webb N, Feisst M, Krupka K, Becker J, Bald M, et al.
Pediatr Nephrol
. 2024 Aug;
39(12):3569-3580.
PMID: 39110227
Background: Complement 3 glomerulopathy (C3G) and immune complex membranoproliferative glomerulonephritis (IC-MPGN) are ultra-rare chronic kidney diseases with an overall poor prognosis, with approximately 40-50% of patients progressing to kidney failure...
5.
Vivarelli M, Bomback A, Meier M, Wang Y, Webb N, Veldandi U, et al.
Kidney Int Rep
. 2024 Feb;
9(1):64-72.
PMID: 38312795
Introduction: Immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN) is an ultra-rare, fast-progressing kidney disease that may be idiopathic (primary) or secondary to chronic infection, autoimmune disorders, or monoclonal gammopathies. Dysregulation of the...
6.
Wong E, Nester C, Cavero T, Karras A, le Quintrec M, Lightstone L, et al.
Kidney Int Rep
. 2023 Dec;
8(12):2754-2764.
PMID: 38106570
Introduction: Complement 3 glomerulopathy (C3G) is a rare inflammatory kidney disease mediated by dysregulation of the alternative complement pathway. No targeted therapy exists for this aggressive glomerulonephritis. Efficacy, safety, tolerability,...
7.
Munch J, Sessler I, Bosse H, Wargenau M, Dreesen J, Loforese G, et al.
Pharmaceutics
. 2023 Jun;
15(6).
PMID: 37376177
Mini-tablets are advantageous over liquid formulations in overcoming challenges related to stability, taste, and dosage. This open-label, single-dose, cross-over study investigated the acceptability and safety of drug-free, film-coated mini-tablets in...
8.
Bomback A, Kavanagh D, Vivarelli M, Meier M, Wang Y, Webb N, et al.
Kidney Int Rep
. 2022 Oct;
7(10):2150-2159.
PMID: 36217526
Introduction: Complement 3 glomerulopathy (C3G) is a rare kidney disease characterized by dysregulation of the alternative pathway (AP) of the complement system. About 50% of patients with C3G progress to...
9.
Levtchenko E, Servais A, Hulton S, Ariceta G, Emma F, Game D, et al.
Clin Kidney J
. 2022 Aug;
15(9):1675-1684.
PMID: 36003666
Cystinosis, a rare autosomal recessive lysosomal storage disorder, results in an abnormal accumulation of the amino acid cystine in multiple organs and tissues of the body. Renal symptoms typically develop...
10.
Afentou N, Frew E, Mehta S, Ives N, Woolley R, Brettell E, et al.
Pharmacoecon Open
. 2022 Jun;
6(4):605-617.
PMID: 35733076
Background: Childhood steroid-sensitive nephrotic syndrome is a frequently relapsing disease with significant short- and long-term complications, leading to high healthcare costs and reduced quality of life for patients. The majority...