Nicholas Hoppe
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Explore the profile of Nicholas Hoppe including associated specialties, affiliations and a list of published articles.
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8
Citations
74
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Recent Articles
1.
Howard M, Hoppe N, Huang X, Mitrovic D, Billesbolle C, Macdonald C, et al.
Cell
. 2025 Jan;
188(3):671-687.e20.
PMID: 39753132
Three proton-sensing G protein-coupled receptors (GPCRs)-GPR4, GPR65, and GPR68-respond to extracellular pH to regulate diverse physiology. How protons activate these receptors is poorly understood. We determined cryogenic-electron microscopy (cryo-EM) structures...
2.
Howard M, Hoppe N, Huang X, Macdonald C, Mehrota E, Rockefeller Grimes P, et al.
bioRxiv
. 2024 Apr;
PMID: 38659943
Three proton-sensing G protein-coupled receptors (GPCRs), GPR4, GPR65, and GPR68, respond to changes in extracellular pH to regulate diverse physiology and are implicated in a wide range of diseases. A...
3.
Hoppe N, Harrison S, Hwang S, Chen Z, Karelina M, Deshpande I, et al.
Nat Struct Mol Biol
. 2024 Feb;
31(4):667-677.
PMID: 38326651
The orphan G protein-coupled receptor (GPCR) GPR161 plays a central role in development by suppressing Hedgehog signaling. The fundamental basis of how GPR161 is activated remains unclear. Here, we determined...
4.
Hoppe N, Harrison S, Hwang S, Chen Z, Karelina M, Deshpande I, et al.
bioRxiv
. 2023 Jun;
PMID: 37292845
The orphan G protein-coupled receptor (GPCR) GPR161 is enriched in primary cilia, where it plays a central role in suppressing Hedgehog signaling. GPR161 mutations lead to developmental defects and cancers....
5.
Faust B, Billesbolle C, Suomivuori C, Singh I, Zhang K, Hoppe N, et al.
Nature
. 2022 Aug;
609(7928):846-853.
PMID: 35940205
Thyroid hormones are vital in metabolism, growth and development. Thyroid hormone synthesis is controlled by thyrotropin (TSH), which acts at the thyrotropin receptor (TSHR). In patients with Graves' disease, autoantibodies...
6.
Zhang K, Wu H, Hoppe N, Manglik A, Cheng Y
Nat Commun
. 2022 Jul;
13(1):4366.
PMID: 35902590
Single particle cryogenic-electron microscopy (cryo-EM) is used extensively to determine structures of activated G protein-coupled receptors (GPCRs) in complex with G proteins or arrestins. However, applying it to GPCRs without...
7.
Nishikawa K, Hoppe N, Smith R, Bingman C, Raman S
Nat Commun
. 2021 Sep;
12(1):5562.
PMID: 34548494
Epistasis is a major determinant in the emergence of novel protein function. In allosteric proteins, direct interactions between inducer-binding mutations propagate through the allosteric network, manifesting as epistasis at the...
8.
Crawford E, Acosta I, Ahyong V, Anderson E, Arevalo S, Asarnow D, et al.
PLoS Pathog
. 2020 Oct;
16(10):e1008966.
PMID: 33112933
No abstract available.