Nicholas F Dupuis
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Explore the profile of Nicholas F Dupuis including associated specialties, affiliations and a list of published articles.
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15
Citations
863
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Recent Articles
1.
Dupuis N, Holmstrom E, Nesbitt D
J Phys Chem B
. 2018 Aug;
122(38):8796-8804.
PMID: 30078323
Dissipation and friction influence the conformational dynamics of biological polymers as they traverse barriers on rugged free energy surfaces. It is well established that the "speed limit" for macromolecular folding...
2.
Holmstrom E, Dupuis N, Nesbitt D
J Phys Chem B
. 2015 Jan;
119(9):3687-96.
PMID: 25621404
The influential role of monovalent and divalent metal cations in facilitating conformational transitions in both RNA and DNA has been a target of intense biophysical research efforts. However, organic neutrally...
3.
Susa A, Wu C, Bernstein S, Dupuis N, Wang H, Raleigh D, et al.
J Am Chem Soc
. 2014 Aug;
136(37):12912-9.
PMID: 25144879
Human islet amyloid polypeptide (hIAPP or Amylin) is a 37 residue hormone that is cosecreted with insulin from the pancreatic islets. The aggregation of hIAPP plays a role in the...
4.
Dupuis N, Holmstrom E, Nesbitt D
Proc Natl Acad Sci U S A
. 2014 May;
111(23):8464-9.
PMID: 24850865
The effects of "molecular crowding" on elementary biochemical processes due to high solute concentrations are poorly understood and yet clearly essential to the folding of nucleic acids and proteins into...
5.
Holmstrom E, Dupuis N, Nesbitt D
Biophys J
. 2014 Jan;
106(1):220-31.
PMID: 24411254
Single-molecule fluorescence spectroscopy is a powerful technique that makes it possible to observe the conformational dynamics associated with biomolecular processes. The addition of precise temperature control to these experiments can...
6.
Dupuis N, Holmstrom E, Nesbitt D
Biophys J
. 2013 Aug;
105(3):756-66.
PMID: 23931323
In this work, the kinetics of short, fully complementary oligonucleotides are investigated at the single-molecule level. Constructs 6-9 bp in length exhibit single exponential kinetics over 2 orders of magnitude...
7.
Bleiholder C, Dupuis N, Bowers M
J Phys Chem B
. 2013 Jan;
117(6):1770-9.
PMID: 23323631
We have probed the structures and aggregation propensities of chirally substituted [Ala(2)]-Leu-Enkephalin peptides (i.e., Leu-Enkephalin G2A) with a combination of ion-mobility spectrometry/mass spectrometry and techniques of computational chemistry. Our IMS/MS...
8.
Dupuis N, Wu C, Shea J, Bowers M
J Am Chem Soc
. 2011 Apr;
133(19):7240-3.
PMID: 21517093
Early oligomerization of human IAPP (hIAPP) is responsible for β-cell death in the pancreas and is increasingly considered a primary pathological process linked to Type II Diabetes (T2D). Yet, the...
9.
Bleiholder C, Dupuis N, Wyttenbach T, Bowers M
Nat Chem
. 2011 Jan;
3(2):172-7.
PMID: 21258392
Amyloid cascades that lead to peptide β-sheet fibrils and plaques are central to many important diseases. Recently, intermediate assemblies of these cascades were identified as the toxic agents that interact...
10.
Bernstein S, Dupuis N, Lazo N, Wyttenbach T, Condron M, Bitan G, et al.
Nat Chem
. 2010 Aug;
1(4):326-31.
PMID: 20703363
In recent years, small protein oligomers have been implicated in the aetiology of a number of important amyloid diseases, such as type 2 diabetes, Parkinson's disease and Alzheimer's disease. As...