Nicholas E Bush
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Explore the profile of Nicholas E Bush including associated specialties, affiliations and a list of published articles.
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13
Citations
133
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Recent Articles
1.
Chou G, Bush N, Phillips R, Baertsch N, Harris K
eNeuro
. 2024 Jan;
11(3).
PMID: 38253582
The preBötzinger complex (preBötC), located in the medulla, is the essential rhythm-generating neural network for breathing. The actions of opioids on this network impair its ability to generate robust, rhythmic...
2.
Severs L, Bush N, Quina L, Hidalgo-Andrade S, Burgraff N, Dashevskiy T, et al.
Nat Commun
. 2023 Aug;
14(1):5300.
PMID: 37652903
Sighs prevent the collapse of alveoli in the lungs, initiate arousal under hypoxic conditions, and are an expression of sadness and relief. Sighs are periodically superimposed on normal breaths, known...
3.
Burgraff N, Phillips R, Severs L, Bush N, Baertsch N, Ramirez J
J Neurophysiol
. 2022 Jun;
128(1):181-196.
PMID: 35675444
Cellular and network properties must be capable of generating rhythmic activity that is both flexible and stable. This is particularly important for breathing, a rhythmic behavior that dynamically adapts to...
4.
Burgraff N, Bush N, Ramirez J, Baertsch N
J Neurosci
. 2021 Oct;
41(48):9919-9931.
PMID: 34697095
Death from opioid overdose is typically caused by opioid-induced respiratory depression (OIRD). A particularly dangerous characteristic of OIRD is its apparent unpredictability. The respiratory consequences of opioids can be surprisingly...
5.
Baertsch N, Bush N, Burgraff N, Ramirez J
Elife
. 2021 Aug;
10.
PMID: 34402425
The analgesic utility of opioid-based drugs is limited by the life-threatening risk of respiratory depression. Opioid-induced respiratory depression (OIRD), mediated by the μ-opioid receptor (MOR), is characterized by a pronounced...
6.
Bush N, Solla S, Hartmann M
Proc Natl Acad Sci U S A
. 2021 Aug;
118(32).
PMID: 34353902
Across all sensory modalities, first-stage sensory neurons are an information bottleneck: they must convey all information available for an animal to perceive and act in its environment. Our understanding of...
7.
Zweifel N, Bush N, Abraham I, Murphey T, Hartmann M
Proc Natl Acad Sci U S A
. 2021 Jul;
118(27).
PMID: 34210794
As it becomes possible to simulate increasingly complex neural networks, it becomes correspondingly important to model the sensory information that animals actively acquire: the biomechanics of sensory acquisition directly determines...
8.
Ramirez J, Karlen-Amarante M, Ju Wang J, Bush N, Carroll M, Weese-Mayer D, et al.
Physiology (Bethesda)
. 2020 Oct;
35(6):375-390.
PMID: 33052774
Rett syndrome (RTT), an X-chromosome-linked neurological disorder, is characterized by serious pathophysiology, including breathing and feeding dysfunctions, and alteration of cardiorespiratory coupling, a consequence of multiple interrelated disturbances in the...
9.
Furuta T, Bush N, Yang A, Ebara S, Miyazaki N, Murata K, et al.
Curr Biol
. 2020 Feb;
30(5):815-826.e5.
PMID: 32004452
Compared to our understanding of the response properties of receptors in the auditory and visual systems, we have only a limited understanding of the mechanoreceptor responses that underlie tactile sensation....
10.
Bush N, Zweifel N, Hartmann M
Neuron
. 2019 Jun;
102(5):911-913.
PMID: 31170398
A recent Nature paper shows that activity in rodent forelimb somatosensory cortex is related to the animal's behavioral report of vibration intensity and identifies candidate mechanoreceptors responsible for the cortical...