Nicholas C Lammers
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Explore the profile of Nicholas C Lammers including associated specialties, affiliations and a list of published articles.
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10
Citations
202
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Recent Articles
1.
Berrocal A, Lammers N, Garcia H, Eisen M
Elife
. 2024 Dec;
12.
PMID: 39651963
Transcription often occurs in bursts as gene promoters switch stochastically between active and inactive states. Enhancers can dictate transcriptional activity in animal development through the modulation of burst frequency, duration,...
2.
Zhao J, Lammers N, Alamos S, Kim Y, Martini G, Garcia H
Nat Commun
. 2024 Oct;
15(1):9263.
PMID: 39461978
Transcriptional control is fundamental to cellular function. However, despite knowing that transcription factors can repress or activate specific genes, how these functions are implemented at the molecular level has remained...
3.
Optogenetic control of YAP reveals a dynamic communication code for stem cell fate and proliferation
Meyer K, Lammers N, Bugaj L, Garcia H, Weiner O
Nat Commun
. 2023 Oct;
14(1):6929.
PMID: 37903793
YAP is a transcriptional regulator that controls pluripotency, cell fate, and proliferation. How cells ensure the selective activation of YAP effector genes is unknown. This knowledge is essential to rationally...
4.
Lammers N, Flamholz A, Garcia H
Proc Natl Acad Sci U S A
. 2023 Mar;
120(10):e2211203120.
PMID: 36862689
Gene regulation is central to cellular function. Yet, despite decades of work, we lack quantitative models that can predict how transcriptional control emerges from molecular interactions at the gene locus....
5.
Berrocal A, Lammers N, Garcia H, Eisen M
bioRxiv
. 2023 Feb;
PMID: 36798351
Transcription often occurs in bursts as gene promoters switch stochastically between active and inactive states. Enhancers can dictate transcriptional activity in animal development through the modulation of burst frequency, duration,...
6.
Live imaging and biophysical modeling support a button-based mechanism of somatic homolog pairing in
Child 6th M, Bateman J, Jahangiri A, Reimer A, Lammers N, Sabouni N, et al.
Elife
. 2021 Jun;
10.
PMID: 34100718
Three-dimensional eukaryotic genome organization provides the structural basis for gene regulation. In , genome folding is characterized by somatic homolog pairing, where homologous chromosomes are intimately paired from end to...
7.
Berrocal A, Lammers N, Garcia H, Eisen M
Elife
. 2020 Dec;
9.
PMID: 33300492
We used live imaging to visualize the transcriptional dynamics of the gene at single-cell and high-temporal resolution as its seven stripe expression pattern forms, and developed tools to characterize and...
8.
Lammers N, Kim Y, Zhao J, Garcia H
Curr Opin Cell Biol
. 2020 Nov;
67:147-157.
PMID: 33242838
Eukaryotic transcription generally occurs in bursts of activity lasting minutes to hours; however, state-of-the-art measurements have revealed that many of the molecular processes that underlie bursting, such as transcription factor...
9.
Lammers N, Galstyan V, Reimer A, Medin S, Wiggins C, Garcia H
Proc Natl Acad Sci U S A
. 2019 Dec;
117(2):836-847.
PMID: 31882445
Predicting how interactions between transcription factors and regulatory DNA sequence dictate rates of transcription and, ultimately, drive developmental outcomes remains an open challenge in physical biology. Using stripe 2 of...
10.
Falo-Sanjuan J, Lammers N, Garcia H, Bray S
Dev Cell
. 2019 Aug;
50(4):411-425.e8.
PMID: 31378591
Information from developmental signaling pathways must be accurately decoded to generate transcriptional outcomes. In the case of Notch, the intracellular domain (NICD) transduces the signal directly to the nucleus. How...