Nicholas A Delamere
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Explore the profile of Nicholas A Delamere including associated specialties, affiliations and a list of published articles.
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64
Citations
975
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Recent Articles
1.
Shahidullah M, Mandal A, Delamere N
J Cell Physiol
. 2024 Jul;
239(11):e31369.
PMID: 39014912
Previously we showed hyperosmotic solution caused TRPV1-dependent NKCC1 activation in the lens by a mechanism that involved ERK1/2 signaling. In various tissues, integrins and the cytoskeletal network play a role...
2.
Zhou Y, Bennett T, Ruzycki P, Guo Z, Cao Y, Shahidullah M, et al.
Cells
. 2024 Feb;
13(3.
PMID: 38334649
TRPM3 belongs to the melastatin sub-family of transient receptor potential (TRPM) cation channels and has been shown to function as a steroid-activated, heat-sensitive calcium ion (Ca) channel. A missense substitution...
3.
Ek-Vitorin J, Shahidullah M, Lopez Rosales J, Delamere N
Front Pharmacol
. 2023 Mar;
14:1101498.
PMID: 36909173
ATP release from the lens hemichannels has been explained as a response to TRPV4 activation when the lens is subjected to osmotic swelling. To explore the apparent linkage between TRPV4...
4.
Shahidullah M, Delamere N
Int J Mol Sci
. 2023 Jan;
24(2).
PMID: 36675184
Previously, we reported a mechanosensitive ion channel, TRPV4, along with functional connexin hemichannels on the basolateral surface of the ocular nonpigmented ciliary epithelium (NPE). In the lens, TRPV4-mediated hemichannel opening...
5.
Gao Y, Mack A, Litteral C, Delamere N, El-Mallakh R
Sci Rep
. 2022 Jun;
12(1):10437.
PMID: 35729322
Dysregulation of ion flux across membranes and glutamate-induced excitotoxicity appear to be important pathophysiologic abnormalities in bipolar illness. Understanding ion control and responses to ionic stress is important to decipher...
6.
Delamere N, Shahidullah M
Front Physiol
. 2022 Feb;
12:834916.
PMID: 35173627
Aside from a monolayer of epithelium at the anterior surface, the lens is formed by tightly compressed multilayers of fiber cells, most of which are highly differentiated and have a...
7.
Delamere N, Shahidullah M, Mathias R, Gao J, Sun X, Sellitto C, et al.
Invest Ophthalmol Vis Sci
. 2020 Jun;
61(6):58.
PMID: 32598448
Purpose: The lens uses feedback to maintain zero pressure in its surface cells. Positive pressures are detected by transient receptor potential vanilloid (TRPV4), which initiates a cascade that reduces surface...
8.
Shahidullah M, Mandal A, Mathias R, Gao J, Krizaj D, Redmon S, et al.
Am J Physiol Cell Physiol
. 2020 Apr;
318(5):C969-C980.
PMID: 32293931
The porcine lens response to a hyperosmotic stimulus involves an increase in the activity of an ion cotransporter sodium-potassium/two-chloride cotransporter 1 (NKCC1). Recent studies with agonists and antagonists pointed to...
9.
Gao Y, Lohano K, Delamere N, Lei Z, El-Mallakh R
Bipolar Disord
. 2018 Dec;
21(2):179-181.
PMID: 30536523
No abstract available.
10.
Shahidullah M, Mandal A, Delamere N
Am J Physiol Cell Physiol
. 2018 Sep;
315(6):C793-C802.
PMID: 30207782
Lens ion homeostasis is crucial in maintaining water content and, in turn, refractive index and transparency of the multicellular syncytium-like structure. New information is emerging on the regulation of ion...