Nerina C van der Merwe
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Explore the profile of Nerina C van der Merwe including associated specialties, affiliations and a list of published articles.
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10
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76
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Recent Articles
1.
van der Merwe N, Buccimazza I, Rossouw B, Araujo M, Ntaita K, Schoeman M, et al.
Breast Cancer Res Treat
. 2024 May;
207(2):331-342.
PMID: 38814507
Purpose: Genetically predisposed breast cancer (BC) patients represent a minor but clinically meaningful subgroup of the disease, with 25% of all cases associated with actionable variants in BRCA1/2. Diagnostic implementation...
2.
Oosthuizen J, van der Merwe N, Kotze M
Front Genet
. 2024 Jan;
14:1330946.
PMID: 38259622
Breast cancer is a significant global health issue as it represents the leading cause of death in women worldwide. In 2021, the World Health Organization established the Global Breast Cancer...
3.
Okunola A, Baatjes K, Zemlin A, Torrorey-Sawe R, Conradie M, Kidd M, et al.
Expert Rev Mol Diagn
. 2023 Apr;
23(5):431-443.
PMID: 37060281
Background: Pathology-supported genetic testing (PSGT) enables transitioning of risk stratification from the study population to the individual. Research Design And Methods: We provide an overview of the translational research performed...
4.
van der Merwe N, Ntaita K, Stofberg H, Combrink H, Oosthuizen J, Kotze M
Front Oncol
. 2022 Dec;
12:938561.
PMID: 36568162
Translation of genomic knowledge into public health benefits requires the implementation of evidence-based recommendations in clinical practice. In this study, we moved beyond susceptibility testing in breast and ovarian cancer...
5.
van der Merwe N, Combrink H, Ntaita K, Oosthuizen J
Front Genet
. 2022 Apr;
13:834265.
PMID: 35464868
Breast cancer is a multifaceted disease that currently represents a leading cause of death in women worldwide. Over the past two decades (1998-2020), the National Health Laboratory Service's Human Genetics...
6.
Mampunye L, van der Merwe N, Grant K, Peeters A, Torrorey-Sawe R, French D, et al.
Front Oncol
. 2021 Oct;
11:619817.
PMID: 34660253
Research performed in South African (SA) breast, ovarian and prostate cancer patients resulted in the development of a rapid BRCA point-of-care (POC) assay designed as a time- and cost-effective alternative...
7.
Combrink H, Oosthuizen J, Visser B, Chabilal N, Buccimazza I, Foulkes W, et al.
Cancer Genet
. 2021 Jul;
258-259:1-6.
PMID: 34218100
Knowledge of the genetic landscape of a specific population group is vital for population-specific diagnosis and treatment of familial breast cancer. Although BRCA-related diagnostic testing has long been implemented in...
8.
Oosthuizen J, Kotze M, Van Der Merwe N, Myburgh E, Bester P, van der Merwe N
Front Oncol
. 2021 Mar;
10:619469.
PMID: 33643918
Breast cancer patients historically benefitted from population-based genetic research performed in South Africa, which led to the development of founder-based diagnostic tests. With the advent of next-generation sequencing (NGS) technologies,...
9.
van der Merwe N, Oosthuizen J, Theron M, Chong G, Foulkes W
BMC Cancer
. 2020 May;
20(1):391.
PMID: 32375709
Background: Pathogenic variants that occur in the familial breast cancer genes (BRCA1/2) lead to truncated ineffective proteins in the majority of cases. These variants are mostly represented by small deletions/insertions,...
10.
Reeves M, Yawitch T, van der Merwe N, van den Berg H, Dreyer G, van Rensburg E
Int J Cancer
. 2004 May;
110(5):677-82.
PMID: 15146556
Germ-line mutations within BRCA1 are responsible for different proportions of inherited susceptibility to breast/ovarian cancer, and the spectrum of mutations within this gene is often unique to certain populations. At...